vavilovВавиловский журнал генетики и селекцииVavilov Journal of Genetics and Breeding2500-3259Institute of Cytology and Genetics of Siberian Branch of the RASvavilov-121Research ArticleСтатьиArticlesРЕДЕРИВАЦИЯ ПУТЕМ ТРАНСПЛАНТАЦИИ ЭМБРИОНОВ ЛИНИЙ ЛАБОРАТОРНЫХ МЫШЕЙ И КРЫСREDERIVATION BY EMBRYO TRANSFER IN STRAINS OF LABORATORY MICE AND RATSАмстиславскийС. Я.AmstislavskyS. Ya.amstis@bionet.nsc.ruИгонинаТ. Н.IgoninaT. N.amstis@bionet.nsc.ruРожковаИ. Н.RozhkovaI. N.amstis@bionet.nsc.ruБрусенцевЕ. Ю.BrusentsevE. Yu.amstis@bionet.nsc.ruРоговаяА. А.RogovayaA. A.РагаеваД. С.RagaevaD. S.НапримеровВ. А.NaprimerovV. A.amstis@bionet.nsc.ruЛитвиноваЕ. А.LitvinovaE. A.amstis@bionet.nsc.ruПлюснинаИ. Ф.PlyusninaI. Z.amstis@bionet.nsc.ruМаркельА. Л.MarkelA. L.amstis@bionet.nsc.ruФедеральное государственное бюджетное учреждение науки Институт цитологии и генетики Сибирского отделения Российской академии наук, Новосибирск, Россия Новосибирский национальный исследовательский государственный университет, Новосибирск, РоссияРоссияInstitute of Cytology and Genetics SB RAS, Novosibirsk, Russia Novosibirsk National Research State University, Novosibirsk, RussiaRussian FederationФедеральное государственное бюджетное научное учреждение «Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук», Новосибирск, РоссияРоссияInstitute of Cytology and Genetics SB RAS, Novosibirsk, RussiaRussian FederationФедеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Новосибирский национальный исследовательский государственный университет" (НГУ)РоссияNovosibirsk National Research State University, Novosibirsk, RussiaRussian FederationФедеральное государственное бюджетное научное учреждение «Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук», Новосибирск, РоссияРоссияNovosibirsk National Research State University, Novosibirsk, RussiaRussian FederationФедеральное государственное бюджетное учреждение науки Институт цитологии и генетики Сибирского отделения Российской академии наук, Новосибирск, Россия Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования Новосибирский государственный аграрный университет, Новосибирск, РоссияРоссияInstitute of Cytology and Genetics SB RAS, Novosibirsk, Russia State Higher Education Institution Novosibirsk State Agrarian University, Novosibirsk, RussiaRussian Federation201320122014171147161Copyright © Амстиславский С.Я., Игонина Т.Н., Рожкова И.Н., Брусенцев Е.Ю., Роговая А.А., Рагаева Д.С., Напримеров В.А., Литвинова Е.А., Плюснина И.Ф., Маркель А.Л., 20142014Амстиславский С.Я., Игонина Т.Н., Рожкова И.Н., Брусенцев Е.Ю., Роговая А.А., Рагаева Д.С., Напримеров В.А., Литвинова Е.А., Плюснина И.Ф., Маркель А.Л.Amstislavsky S.Y., Igonina T.N., Rozhkova I.N., Brusentsev E.Y., Rogovaya A.A., Ragaeva D.S., Naprimerov V.A., Litvinova E.A., Plyusnina I.Z., Markel A.L.This work is licensed under a Creative Commons Attribution 4.0 License.https://vavilov.elpub.ru/jour/article/view/121

Редеривация позволяет очистить колонии лабораторных мышей и крыс от специфических патогенов и перевести их в SPF (specified pathogen free) статус. В данной работе приведены результаты редеривации двух уникальных линий крыс, селекционированных в ИЦиГ СО РАН: ручных крыс-пасюков, крыс с наследственной индуцированной стрессом артериальной гипертензией (НИСАГ) и линии мышей ICR. SPF-статус редеривированных крыс был подтвержден при помощи животных-индикаторов, называемых также сентинелами (sentinel animals). В статье предложена оптимизированная модель редеривации лабораторных животных, которая включает в себя набор эмбриотехнологических методов, таких, как замораживание и криоконсервация эмбрионов, их очистка путем отмывки в стерильных средах, культивирование 48 ч и, наконец, трансплантация реципиентам (SPF-статуса). В результате применения этой модели по отношению к мышам линии ICR удалось получить 39 потомков, рожденных в условиях SPF-вивария. Следует отметить, что эффективность процедуры вполне соответствует международным стандартам, причем все три линии демонстрировали характерный фенотип после прохождения всех процедур редеривации.

Rederivation allows laboratory animal populations to be purged from specified pathogens and thus turns these animals to the SPF (specified pathogens free) status. Results of the rederivation of two unique rat strains selected at the Institute of Cytology and Genetics and one mouse strain are presented. The two rat strains are: tame Norway rats and rats with Inherited Stress Induced Arterial Hypertension (ISIAH strain). The ICR mouse strain has been named as abbreviation of the Institute of Cancer Research wherefrom these mice were distributed to laboratories all over the world. The SPF status of the rats after rederivation was confirmed by the method of indicator animals (sentinel animals). The optimized model of rederivation offered here involves a combination of such embryotechnological methods as freezing/cryopreservation of embryos, their washing through the number of fresh volumes of sterile media, growing in vitro for 48 hours, and subsequent transfer into either one or both uterine horns of recipient females. Application of this model to rederivation of ICR mice yielded 39 pups born in an SPF vivarium. It should be noticed that the effectiveness of the procedure met international standards, and characteristic features of phenotype were retained in all the three strains after rederivation.

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The authors declare that there are no conflicts of interest present.