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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vavilov</journal-id><journal-title-group><journal-title xml:lang="ru">Вавиловский журнал генетики и селекции</journal-title><trans-title-group xml:lang="en"><trans-title>Vavilov Journal of Genetics and Breeding</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2500-3259</issn><publisher><publisher-name>Institute of Cytology and Genetics of Siberian Branch of the RAS</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18699/VJ17.301</article-id><article-id custom-type="elpub" pub-id-type="custom">vavilov-1231</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ТЕСТ-СИСТЕМЫ И БИОИСПЫТАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>TEST SYSTEMS AND BIOTESTS</subject></subj-group></article-categories><title-group><article-title>Связь между фенотипической робастностью  и средней продолжительностью жизни  у Drosophila melanogaster</article-title><trans-title-group xml:lang="en"><trans-title>A link between phenotypic robustness and life expectancy in Drosophila melanogaster</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Захаренко</surname><given-names>Л. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Zakharenko</surname><given-names>L. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Новосибирск.</p></bio><bio xml:lang="en"><p>Novosibirsk.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петровский</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrovskii</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Новосибирск.</p></bio><bio xml:lang="en"><p>Novosibirsk.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дранов</surname><given-names>И. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Dranov</surname><given-names>I. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Новосибирск.</p></bio><bio xml:lang="en"><p>Novosibirsk.</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Федорова</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Fedorova</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Новосибирск.</p></bio><bio xml:lang="en"><p>Novosibirsk.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Юдин</surname><given-names>Н. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Yudin</surname><given-names>N. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Новосибирск.</p></bio><bio xml:lang="en"><p>Novosibirsk.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пиндюрин</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Pindyurin</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Новосибирск.</p></bio><bio xml:lang="en"><p>Novosibirsk.</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мошкин</surname><given-names>Ю. М.</given-names></name><name name-style="western" xml:lang="en"><surname> Moshkin</surname><given-names>Y. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Новосибирск.</p></bio><bio xml:lang="en"><p>Novosibirsk.</p></bio><email xlink:type="simple">yury.moshkin@gmail.com</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук.<country>Россия</country></aff><aff xml:lang="en">Institute of Cytology and Genetics SB RAS.<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Институт химической кинетики и горения им. В.В. Воеводского Сибирского отделения Российской академии наук.<country>Россия</country></aff><aff xml:lang="en">Voevodsky Institute of Chemical Kinetics and Combustion  SB RAS.<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">Институт молекулярной и клеточной биологии Сибирского отделения Российской академии наук.<country>Россия</country></aff><aff xml:lang="en">Institute of Molecular and Cellular Biology SB RAS.<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru">Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук; Институт молекулярной и клеточной биологии Сибирского отделения Российской академии наук.<country>Россия</country></aff><aff xml:lang="en">Institute of Cytology and Genetics SB RAS; Institute of Molecular and Cellular Biology SB RAS.<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>23</day><month>12</month><year>2017</year></pub-date><volume>21</volume><issue>7</issue><fpage>816</fpage><lpage>824</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Захаренко Л.П., Петровский Д.В., Дранов И.Г., Федорова С.А., Юдин Н.С., Пиндюрин А.В., Мошкин Ю.М., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Захаренко Л.П., Петровский Д.В., Дранов И.Г., Федорова С.А., Юдин Н.С., Пиндюрин А.В., Мошкин Ю.М.</copyright-holder><copyright-holder xml:lang="en">Zakharenko L.P., Petrovskii D.V., Dranov I.G., Fedorova S.A., Yudin N.S., Pindyurin A.V.,  Moshkin Y.M.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vavilov.elpub.ru/jour/article/view/1231">https://vavilov.elpub.ru/jour/article/view/1231</self-uri><abstract><p>Любая долгоживущая система должна быть стабильной, т. е. обладать повышенной устойчивостью как к внешним воздействиям, так и к внутренним сбоям. Робастность биологических систем может быть определена как реципрокная величина к фенотипической изменчивости или, для положительно распределенных признаков, к коэффициенту вариации (C.V.). Рассматривая продолжительность жизни как интегральный фенотип всех функций организма, мы показали, что фенотипическая робастность организма положительно коррелирует с ожидаемой продолжительностью жизни. Мы определили параметры продолжительности жизни для ряда инбредных линий Drosophila melanogaster, выращенных при 29 ºС, из коллекции Drosophila Genetic Reference Panel (DGRP). Фенотипическая робастность продолжительности жизни (C.V.–1) для этих линий коррелировала положительно с ожидаемой продолжительностью жизни. Соотношение между робастностью и ожидаемой продолжительностью жизни сохраняется и для DGRP линий, выра щенных при 25 ºС. Помимо этого, в соответствии с ранее опубли кованными результатами, с изменением (уменьшением или увели чением) температуры кривые дожития масштабируются (растягиваются или сжимаются соответственно) по временной шкале. Иными словами, с увеличением температуры падает как средняя продолжительность жизни, так и стандартное отклонение от средней продолжительности жизни, в то время как коэффициенты вариации сохраняются в том же диапазоне. Исходя из этого, мы заключили, что коэффициенты вариации коррелируют со средней продолжительностью жизни и отражают фенотипическую робастность продолжительности жизни даже при ускоренном старении, вызванном температурой.</p></abstract><trans-abstract xml:lang="en"><p>Long-lived systems are expected to be stable, i. e. resistant to either external influences, or internal failures. Robustness of biological systems can be defined as a reciprocal value to their phenotypic plasticity expressed through a coefficient of variation (C.V.) for positively distributed phenotypic traits. Considering lifespan as phenotype, which integrates all functions of an organism, we showed that its phenotypic robustness correlates positively with life expectancy. We assessed lifespan parameters for a selection of inbred Drosophila melanogaster strains from Drosophila Genetic Reference Panel (DGRP) reared at 29 ºС. The robustness of lifespan phenotype (C.V.–1) correlated positively with estimated life expectancy for these strains. The same relation also holds for the lifespan of all DGRP strains reared at 25 ºС. Also, in agreement with previous observations, upon temperature change (decrease or increase) the survival curves scaled in time (stretched or shrunk respectively). In other words, the average lifespan decreased for flies reared at elevated temperature, but so did the standard deviation, and thus the coefficients of variation remained in the same range. From this we conclude that coefficients of variation correlate with life expectancies and account for the robustness of lifespan phenotype irrespective of accelerated aging caused by temperature.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>продолжительность жизни</kwd><kwd>ожидаемая продолжительность жизни</kwd><kwd>старение</kwd><kwd>фенотипическая изменчивость</kwd><kwd>фенотипическая робастность</kwd><kwd>Drosophila melanogaster</kwd></kwd-group><kwd-group xml:lang="en"><kwd>lifespan</kwd><kwd>life expectancy</kwd><kwd>aging</kwd><kwd>phenotypic plasticity</kwd><kwd>phenotypic robustness</kwd><kwd>Drosophila melanogaster</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ayyadevara S., Alla R., Thaden J.J., Shmookler Reis R.J. Remarkable longevity and stress resistance of nematode PI3K-null mutants. Aging Cell. 2008;7:13-22. 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