References

vavilov

Вавиловский журнал генетики и селекции

Vavilov Journal of Genetics and Breeding

2500-3259

Institute of Cytology and Genetics of Siberian Branch of the RAS

10.18699/VJ17.304

vavilov-1234

Research Article

ТЕСТ-СИСТЕМЫ И БИОИСПЫТАНИЯ

TEST SYSTEMS AND BIOTESTS

Изменение метаболических показателей и двигательной активности у лабораторных мышей под воздействием микроводорослей (Chlorella vulgaris)

Metabolic and motor activity effects of microalgae (Chlorella vulgaris) in laboratory mice

Завьялов

Е. Л.

Zavjalov

E. L.

Новосибирск.

Novosibirsk.

zavjalov@ngs.ru

Петровский

Д. В.

Petrovskii

D. V.

Новосибирск.

Novosibirsk.

Концевая

Г. В.

Kontsevaya

G. V.

Новосибирск.

Novosibirsk.

Мак

В. В.

Mak

V. V.

Новосибирск.

Novosibirsk.

Уваров

И. П.

Uvarov

I. P.

Новосибирск.

Novosibirsk.

Завьялова

Я. Л.

Zav’yalova

Y. L.

Новосибирск.

Novosibirsk.

Рожков

О. А.

Rozhkov

O. A.

Новосибирск.

Novosibirsk.

Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук.РоссияInstitute of Cytology and Genetics SB RAS.Russian Federation

Государственное бюджетное учреждение Новосибирской области «Управление ветеринарии города Новосибирска».РоссияVeterinary control of Novosibirsk.Russian Federation

Новосибирский государственный педагогический университет.РоссияNovosibirsk State Pedagogical University.Russian Federation

Государственное бюджетное учреждение Новосибирской области «Управление ветеринарии Новосибирской области».РоссияVeterinary control of Novosibirsk region.Russian Federation

2017

23122017

217841847

2017

Завьялов Е.Л., Петровский Д.В., Концевая Г.В., Мак В.В., Уваров И.П., Завьялова Я.Л., Рожков О.А.

Zavjalov E.L., Petrovskii D.V., Kontsevaya G.V., Mak V.V., Uvarov I.P., Zav’yalova Y.L., Rozhkov O.A.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://vavilov.elpub.ru/jour/article/view/1234

В последние годы микроводоросли привлекают все больший интерес как источник потенциальных фармакологически активных соединений. На фоне большого разнообразия микроводорослей выделяется зеленая водоросль хлорелла (Chlorella vulgaris), для которой показаны гипотензивные эффекты, антикоагулянтная, антиоксидантная и противоопухолевая активности. Целью насто ящей работы было оценить эффекты суспензии хлореллы на массу тела животных, их двигательную активность и эритропоэз. Иссле дование выполнено на самцах и самках мышей линии ICR. Животным из экспериментальной группы на протяжении трех недель вместо воды предоставляли суспензию хлореллы при стандартной кормовой диете. Масса тела у самцов из контрольной и экспериментальной групп практически не изменялась, тогда как у самок в экспериментальной группе отмечалось увеличение массы тела уже через неделю. Аналогичная ситуация наблюдалась при анализе привеса массы тела животного относительно потребленного корма. В экспериментальной группе количество эритроцитов увеличивалось через три недели после начала исследования как у самок, так и у самцов. Гемоглобин также повышался через три недели после начала эксперимента, но только у самок. Суточная двигательная активность животных всех групп была одинаковой и не изменялась на протяжении исследования. Процедура взятия крови приводила к снижению двигательной активности самцов и самок из контрольной группы и самцов, которые употребляли хлореллу. Двигательная активность самок, которые получали суспензию хлореллы, не изменялась после взятия крови.

In recent years, the microalgae (Chlorella vulgaris) have increasingly attracted great interest as a potential source of pharmacologically active compounds. Showing anticoagulation, antioxidant and antitumor activities of Chlorella revealed its hypotensive properties. The aim of this study was to evaluate the effects of Chlorella suspension on the weight of the animals, their moving activity, and erythropoiesis. The study was performed on males and females of ICR mice. The animals from the experimental group drank only the Chlorella suspension during 3 weeks and were given standard food. Control animals drank during this period only water and had the same food. The body weight of males in the control and the experimental group with Chlorella did not change, while females in the experimental group showed an increase of body weight in a week. A similar pattern was obtained for estimation of animal body weight changes relative to food consumption. The number of red blood cells in females and males from group with Chlorella increased only after 3 weeks after the start of the experiment. Hemoglobin also increased only after 3 weeks after the start of Chlorella consumption, but only for females. All groups of animals had the same motor activity during experiment. Blood sampling resulted in a reduction of activity in control males and females as well as in males with Chlorella. The motor activity of females with Chlorella after blood sampling did not change. So, consumption of the Chlorella suspension by females leads to more effective digestion and resulted in increased body weight, improved erythropoiesis resulted in increased red blood cells and hemoglobin and also increased their resistance to acute stress. The males in the same situation increased only the erythropoiesis.

хлореллаChlorellaмасса теладвигательная активностьэритроцитыгемоглобинлабораторные мыши

Chlorellabody weightmotor activityred blood cellshemoglobinlaboratory mice

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The authors declare that there are no conflicts of interest present.