vavilovВавиловский журнал генетики и селекцииVavilov Journal of Genetics and Breeding2500-3259Institute of Cytology and Genetics of Siberian Branch of the RAS10.18699/VJ18.349vavilov-1443Research ArticleМЕДИЦИНСКАЯ ГЕНЕТИКА, НЕЙРОГЕНЕТИКА, ИММУНОГЕНЕТИКА, БИОМЕДИЦИНАPOPULATION GENETICSПолиморфизм T3111C гена Clock у женщин русской и бурятской национальностиPolymorphism T3111C of the Clock gene in ethnic groups of women from Russia and BuryatiaКалюжнаяО. В.KaluzhnayaO. V.

Иркутск

Irkutsk

СеменоваН. В.SemenovaN. V.

Иркутск

Irkutsk

БаироваТ. А.BairovaT. A.

Иркутск

Irkutsk

МадаеваИ. М. MadaevaI. M.

Иркутск

Irkutsk

БеляеваЕ. В.BelyaevaE. V.

Иркутск

Irkutsk

belyeva_irk@mail.ruКолесниковаЛ. И.KolesnikovaL. I.

Иркутск

Irkutsk

Научный центр проблем здоровья семьи и репродукции человекаРоссияScientific Centre for Family Health and Human Reproduction ProblemsRussian Federation201806042018222212216Copyright © Калюжная О.В., Семенова Н.В., Баирова Т.А., Мадаева И.М., Беляева Е.В., Колесникова Л.И., 20182018Калюжная О.В., Семенова Н.В., Баирова Т.А., Мадаева И.М., Беляева Е.В., Колесникова Л.И.Kaluzhnaya O.V., Semenova N.V., Bairova T.A.,  Madaeva I.M., Belyaeva E.V., Kolesnikova L.I.This work is licensed under a Creative Commons Attribution 4.0 License.https://vavilov.elpub.ru/jour/article/view/1443

В двух выборках женщин климактерического возраста русской и бурятской национальности, проживающих в Восточной Сибири (Иркутская область, г. Иркутск и Республика Бурятия, г. Улан-Удэ), изучена распространенность генотипов и аллелей T3111C полиморфизма гена циркадного ритма Clock (rs1801260). Для этого было проведено генотипирование образцов ДНК методом полимеразной цепной реакции. Показано, что сравниваемые группы статистически значимо отличаются по частоте встречаемости генотипов (р = 0.001). Обнаружено, что в выборке русских женщин больше частота TC генотипа (р = 0.004) и меньше частота TT генотипа (р = 0.0001) по сравнению с выборкой женщин из Бурятии. Аллель с измененной последовательностью 3111С у русских женщин встречался в 30.4 % случаев, что статистически значимо чаще по сравнению с выборкой бурят, где доля аллеля 3111С составила 19.3 % (p = 0.014).

Biological rhythms of organisms depend on both changing conditions of the external environment and internal “biological clock”. Circadian rhythms are the response of the organism to the change of day and night. They are some of the most important biological rhythms of organisms. Circadian rhythms are regulated by the group of circadian genes. It is known that women suffer from sleep disorders more often than men. Up to 50 % of menopausal women complain of problems associated with sleeping. The study involved 403 menopausal women aged from 45 to 60 years: 214 Russians (the average age is 52.74±6.28 years) and 189 Buryats (the average age is 51.95±5.13 years) living in Eastern Siberia (Irkutsk region, Irkutsk and Republic of Buryatia, Ulan-Ude). The prevalence of genotypes and alleles of the polymorphism T3111C of the circadian rhythm gene Clock (rs1801260) was studied in these groups. To this end, we conducted genotyping of DNA samples by polymerase chain reaction. It was shown that the compared groups have statistically significant differences in genotypes frequency (р = 0.001). It was found that in the group of Russian women the frequency of the TC genotype (p = 0.004) was significantly higher and the frequency of the TT genotype (p = 0.0001) was significantly lower than those in the sample of women of Buryatia. It was shown that in the group of Russian women allele 3111C is found in 30.4 % of cases, which is statistically significantly more often than in the group of Buryat women, where the frequency of allele 3111C was 19.3 % (p = 0.014).

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The authors declare that there are no conflicts of interest present.