vavilovВавиловский журнал генетики и селекцииVavilov Journal of Genetics and Breeding2500-3259Institute of Cytology and Genetics of Siberian Branch of the RASvavilov-146Research ArticleСтатьиArticlesЭМБРИОНАЛЬНЫЕ СТВОЛОВЫЕ КЛЕТКИ МЫШИ И ЧЕЛОВЕКАMOUSE AND HUMAN EMBRYONIC STEM CELLSМензоровА. Г.MenzorovA. G.menzorov@bionet.nsc.ruФедеральное государственное бюджетное учреждение науки Институт цитологии и генетики Сибирского отделения Российской академии наук, Новосибирск, Россия; Новосибирский национальный исследовательский государственный университет, Новосибирск, РоссияРоссияInstitute of Cytology and Genetics SB RAS, Novosibirsk, Russia; Novosibirsk National Research State University, Novosibirsk, RussiaRussian Federation201325122014172234245Copyright © Мензоров А.Г., 20142014Мензоров А.Г.Menzorov A.G.This work is licensed under a Creative Commons Attribution 4.0 License.https://vavilov.elpub.ru/jour/article/view/146

Рассмотрены современные представления об эмбриональных стволовых клетках мыши и человека. Обсуждаются предпосылки и методы их получения, стратегия доказательства плюрипотентности, проблемы при долговременном культивировании in vitro. Освещены некоторые проблемы биологии эмбриональных стволовых клеток и перспективы использования для клеточной терапии.

This mini review is focused on the current state in the field of mouse and human embryonic stem (ES) cell biology. Methods of ES cell derivation, pluripotency assessment and problems associated with long term cultivating in vitro are discussed. Attention is given to some unresolved questions of ES cell biology and prospects of ES cells in cell therapy.

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The authors declare that there are no conflicts of interest present.