References

vavilov

Вавиловский журнал генетики и селекции

Vavilov Journal of Genetics and Breeding

2500-3259

Institute of Cytology and Genetics of Siberian Branch of the RAS

10.18699/VJ18.402

vavilov-1587

Research Article

ГЕНЕТИКА ЧЕЛОВЕКА

HUMAN GENETICS

Оценка вклада монгольской экспансии в генофонд тувинцев

Estimating the impact of the Mongol expansion upon the gene pool of Tuvans

Дамба

Л. Д.

Damba

L. D.

Балановская

Е. В.

Balanovskaya

Е. V.

Жабагин

M. К.

Zhabagin

M. K.

Юсупов

Ю. М.

Yusupov

Y. М.

Богунов

Ю. В.

Bogunov

Y. V.

Moscow

Сабитов

Ж. М.

Sabitov

Z. M.

Агджоян

А. Т.

Agdzhoyan

A. T.

Короткова

Н. А.

Korotkova

N. A.

Лавряшина

М. Б.

Lavryashina

M. B.

Монгуш

Б. Б.

Mongush

B. B.

Кавай-оол

У. Н.

Kavai-ool

U. N.

Балановский

О. П.

Balanovsky

O. P.

balanovsky@inbox.ru

НИИ медико-социальных проблем и управления Республики Тыва; Медико-генетический научный центрРоссияResearch Institute of Medical and Social Problems and Control of the Healthcare Department; Research Centre for Medical GeneticsRussian Federation

Медико-генетический научный центр; АНО «Биобанк Северной Евразии»РоссияResearch Centre for Medical Genetics; Biobank of Northern EurasiaRussian Federation

Национальный центр биотехнологииРоссияNational Center for BiotechnologyRussian Federation

Институт стратегических исследований Республики БашкортостанРоссияInstitute for Strategic Studies of the Republic of BashkortostanRussian Federation

Медико-генетический научный центр; Институт общей генетики им. Н.И. Вавилова Российской академии наукРоссияResearch Centre for Medical Genetics Vavilov Institute of General Genetics, RASRussian Federation

Евразийский национальный университет им. Л.Н. ГумилеваРоссияL.N. Gumilyov Eurasian National UniversityRussian Federation

Медико-генетический научный центр: Институт общей генетики им. Н.И. Вавилова Российской академии наукРоссияResearch Centre for Medical Genetics; Vavilov Institute of General Genetics, RASRussian Federation

Кемеровский государственный университетРоссияKemerovo State UniversityRussian Federation

Тувинский институт гуманитарных и прикладных социальноэкономических исследованийРоссияTuvan Institute of Humanitarian and Applied Socio-Economic StudiesRussian Federation

Тувинский государственный университетРоссияTuvan State UniversityRussian Federation

АНО «Биобанк Северной Евразии»; Институт общей генетики им. Н.И. Вавилова Российской академии наукРоссияBiobank of Northern Eurasia; Vavilov Institute of General Genetics, RASRussian Federation

2018

08082018

225611619

2018

Дамба Л.Д., Балановская Е.В., Жабагин M.К., Юсупов Ю.М., Богунов Ю.В., Сабитов Ж.М., Агджоян А.Т., Короткова Н.А., Лавряшина М.Б., Монгуш Б.Б., Кавай-оол У.Н., Балановский О.П.

Damba L.D., Balanovskaya Е.V., Zhabagin M.K., Yusupov Y.М., Bogunov Y.V., Sabitov Z.M., Agdzhoyan A.T., Korotkova N.A., Lavryashina M.B., Mongush B.B., Kavai-ool U.N., Balanovsky O.P.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://vavilov.elpub.ru/jour/article/view/1587

Для выявления следа монгольской экспансии в генофонде тувинцев впервые изучены генофонды двух самых многочисленных тувинских родов, для которых по данным гуманитарных наук ожидается наибольший вклад центральноазиатского компонента, связываемого с монгольской экспансией. При таком подходе результаты исследования могут служить верхней оценкой «монгольского влияния» на генофонд тувинцев в целом. По данным о 59 SNP-маркерах Y-хромосомы спектры гаплогрупп генофондов этих тувинских родов (монгуш, N = 64; ооржак, N = 27) оказались сходными. В среднем две трети их генофондов (63 %) составляют «североевразийские» гаплогруппы (N*, N1a2, N3a, Q), связываемые с автохтонным населением современного ареала тувинцев, тогда как «центральноазиатские» гаплогруппы (C2, O2) составляют менее пятой части (17 %) генофонда изученных тувинских родов. Для монголов наблюдается прямо противоположное соотношение: 10 % «североевразийских» и 75 % «центральноазиатских» гаплогрупп. Все полученные результаты – «генетические портреты», матрица генетических расстояний, дендрограмма и график многомерного шкалирования, отражающие генетические связи тувинских родов с популяциями Южной Сибири и Центральной Азии, свидетельствуют о значительном сходстве генофондов тувинских родов с популяциями Хакасии и Алтая и позволяют сделать вывод о формировании тувинских родов монгуш и ооржак на основе автохтонного населения (предположительно – местного самодийско-кетского субстрата). Малый вклад в генофонд этих родов «центральноазиатских» гаплогрупп позволяет считать, что и на генофонд тувинцев в целом монгольская экспансия не оказала значимого влияния.

With a view to trace the Mongol expansion in Tuvinian gene pool we studied two largest Tuvinian clans – those in which, according to data of humanities, one could expect the highest Central Asian ancestry, connected with the Mongol expansion. Thus, the results of Central Asian ancestry in these two clans component may be used as upper limit of the Mongol influence upon the Tuvinian gene pool in a whole. According to the data of 59 Y-chromosomal SNP markers, the haplogroup spectra in these Tuvinian tribal groups (Mongush, N = 64, and Oorzhak, N = 27) were similar. On average, two-thirds of their gene pools (63 %) are composed by North Eurasian haplogroups (N*, N1a2, N3a, Q) connected with autochtonous populations of modern area of Tuvans. The Central Asian haplogroups (C2, O2) composed less then fifth part (17 %) of gene pools of the clans studied. The opposite ratio was revealed in Mongols: there were 10 % North Eurasian haplogroups and 75 % Central Asian haplogroups in their gene pool. All the results derived – “genetic portraits”, the matrix of genetic distances, the dendrogram and the multidimensional scaling plot, which mirror the genetic connections between Tuvinian clans and populations of South Siberia and East Asia, demonstrated the prominent similarity of the Tuvinian gene pools with populations from and Khakassia and Altai. It could be therefore assumed that Tuvinian clans Mongush and Oorzhak originated from autochtonous people (supposedly, from the local Samoyed and Kets substrata). The minor component of Central Asian haplogroups in the gene pool of these clans allowed to suppose that Mongol expansion did not have a significant influence upon the Tuvinan gene pool at a whole.

Y-хромосомаSNP-полиморфизмгаплогруппаэтногенезродтувинцы

Y-chromosomeSNP-polymorphismhaplogroupethnogenesistribal groupTuvans

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The authors declare that there are no conflicts of interest present.