vavilovВавиловский журнал генетики и селекцииVavilov Journal of Genetics and Breeding2500-3259Institute of Cytology and Genetics of Siberian Branch of the RASvavilov-183Research ArticleСтатьиArticlesSNP_TATA_COMPARATOR: Web -СЕРВИС ПРИМЕНЕНИЯ УРАВНЕНИЯ РАВНОВЕСИЯ ТВР/ТАТА-КОМПЛЕКСА В СРАВНИТЕЛЬНОЙ ОЦЕНКЕ SNPs ПРОМОТОРОВ ГЕНОВ, СВЯЗАННЫХ С БОЛЕЗНЯМИ ЧЕЛОВЕКАSNP_TATA_COMPARATOR: Web SERVICE FOR COMPARISON OF SNPs WITHIN GENE PROMOTЕRS ASSOCIATED WITH HUMAN DISEASES USING THE EQUILIBRIUM EQUATION OF THE TBP/TATA COMPLEXРассказовД. А.RasskazovD. A.pon@bionet.nsc.ruГунбинК. В.GunbinK. V.pon@bionet.nsc.ruПономаренкоП. М.PonomarenkoP. M.pon@bionet.nsc.ruВишневскийО. В.VishnevskyO. V.pon@bionet.nsc.ruПономаренкоМ. П.PonomarenkoM. P.pon@bionet.nsc.ruАфонниковД. А.AfonnikovD. A.pon@bionet.nsc.ruФедеральное государственное бюджетное научное учреждение «Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук», Новосибирск, РоссияРоссияInstitute of Cytology and Genetics SB RAS, Novosibirsk, RussiaRussian FederationФедеральное государственное бюджетное учреждение науки Институт цитологии и генетики Сибирского отделения Российской академии наук, Новосибирск, Россия Новосибирский национальный исследовательский государственный университет, Новосибирск, РоссияРоссияInstitute of Cytology and Genetics SB RAS, Novosibirsk, Russia Novosibirsk National Research State University, Novosibirsk, RussiaRussian Federation201309012015174/1599606Copyright © Рассказов Д.А., Гунбин К.В., Пономаренко П.М., Вишневский О.В., Пономаренко М.П., Афонников Д.А., 20152015Рассказов Д.А., Гунбин К.В., Пономаренко П.М., Вишневский О.В., Пономаренко М.П., Афонников Д.А.Rasskazov D.A., Gunbin K.V., Ponomarenko P.M., Vishnevsky O.V., Ponomarenko M.P., Afonnikov D.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://vavilov.elpub.ru/jour/article/view/183

Исследование проявления полиморфизма регуляторных районов генов на уровне их экспрессии имеет важное фундаментальное и прикладное значение. Создан Web-сервис SNP_TATA_Comparator для применения оценки in silico на основе уравнения равновесия ТВР/ТАТА-комплекса (ТВР, ТАТА-связывающий белок), экспериментально доказанного для биохимических проявлений in vitro, к связанным с болезнями SNP (Single nucleotide polymorphism) кор-промоторов генов человека.В результате обеспечен свободный доступ в режиме «реального времени» к анализу имеющейся персонифицированной информации об отклонениях индивидуальных геномов от так называемого референсного генома человека (Вып. 68, Flicek et al., 2011), т. е. варианта генома, который общепринят в качестве стандарта для сравнительного анализа). При этом автоматически учитываются все доказанные транскрипты гена (база данных GENCODE, Вып. 17). Web-сервис SNP_TATA_Comparator предназначен для диагностики, мониторинга, профилактики и лечения заболеваний с учетом индивидуальных геномов пациентов в рамках персонифицированной медицины.

Web-service SNP_TATA_Comparator has been developed for using experimentally proven in silico evaluation of in vivo biochemical manifestations of SNPs in the core promoter regions of human genes associated with diseases on the base of the TBP/TATA complex equilibrium equation (TBP is TATA binding protein). Data of individual deviations from the reference human genome (Ensembl, rel. 68, i.e. the variant of human genome commonly accepted as datum in comparison analysis) are accessible for free in the real-time mode. Also, data from the GENCODE database (rel. 17) are automatically invoked. The reported Web service SNP_TATA_Comparator is designed for personalized medicine using individual genomes in diagnosis, monitoring, prevention, and treatment.

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The authors declare that there are no conflicts of interest present.