vavilovВавиловский журнал генетики и селекцииVavilov Journal of Genetics and Breeding2500-3259Institute of Cytology and Genetics of Siberian Branch of the RASvavilov-193Research ArticleСтатьиArticlesМАТЕМАТИЧЕСКОЕ МОДЕЛИРОВАНИЕ СИНТЕЗА БИОЭТАНОЛА И МОЛОЧНОЙ КИСЛОТЫ ТЕРМОФИЛЬНЫМИ БАКТЕРИЯМИ РОДА GeobacillusМATHEMATICAL MODELING OF ETHANOL AND LACTIC ACID BIOSYNTHESIS BY THERMOPHILIC Geobacillus BACTERIAНуриддиновМ. А.NuriddinovM. A.akberdin@bionet.nsc.ruКазанцевФ. В.KazantsevF. V.РозановА. С.RozanovA. S.akberdin@bionet.nsc.ruКозловК. Н.KozlovK. N.ПельтекС. Е.PeltekS. E.akberdin@bionet.nsc.ruКолчановН. А.AkberdinI. R.akberdin@bionet.nsc.ruАкбердинИ. Р.KolchanovN. A.akberdin@bionet.nsc.ruФедеральное государственное бюджетное научное учреждение «Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук», Новосибирск, РоссияРоссияInstitute of Cytology and Genetics SB RAS, Novosibirsk, RussiaRussian FederationCанкт-Петеpбуpгcкий гоcудаpcтвенный политеxничеcкий унивеpcитет, Cанкт-Петеpбуpг, РоссияРоссияSt-Petersburg State Polytechnicol university, St-Petersburg, RussiaRussian FederationФедеральное государственное бюджетное учреждение науки Институт цитологии и генетики Сибирского отделения Российской академии наук, Новосибирск, Россия Новосибирский национальный исследовательский государственный университет, Новосибирск, РоссияРоссияInstitute of Cytology and Genetics SB RAS, Novosibirsk, RussiaRussian FederationФедеральное государственное бюджетное научное учреждение «Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук», Новосибирск, РоссияРоссияInstitute of Cytology and Genetics SB RAS, Novosibirsk, Russia Novosibirsk National Research State University, Novosibirsk, RussiaRussian Federation201310012015174/1686704Copyright © Нуриддинов М.А., Казанцев Ф.В., Розанов А.С., Козлов К.Н., Пельтек С.Е., Колчанов Н.А., Акбердин И.Р., 20152015Нуриддинов М.А., Казанцев Ф.В., Розанов А.С., Козлов К.Н., Пельтек С.Е., Колчанов Н.А., Акбердин И.Р.Nuriddinov M.A., Kazantsev F.V., Rozanov A.S., Kozlov K.N., Peltek S.E., Akberdin I.R., Kolchanov N.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://vavilov.elpub.ru/jour/article/view/193

В работе представлена разработанная и адаптированная к имеющимся экспериментальным данным математическая модель биосинтеза биоэтанола и молочной кислоты в клетках Geobacillus sрp. Показано, что математическая модель позволяет осуществлять in silico планирование экспериментов с бактерией Geobacillus sрp. методами молекулярно-генетической инженерии, предсказывать динамику изменения концентрации синтезируемых биоэтанола и молочной кислоты в зависимости от молекулярно-генетических манипуляций с активностью ферментов метаболической системы.

A mathematical model of the ethanol and lactic acid biosynthesis in the cells of Geobacillus spp. developed and adapted to the available experimental data is presented. It is shown that the mathematical model allows in silico design of genetic engineering experiments with the Geobacillus spp. bacterium and prediction of the dynamics of changes in synthesized ethanol and lactic acid concentrations depending on the molecular manipulations with the activity of enzymes of the metabolic system.

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The authors declare that there are no conflicts of interest present.