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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vavilov</journal-id><journal-title-group><journal-title xml:lang="ru">Вавиловский журнал генетики и селекции</journal-title><trans-title-group xml:lang="en"><trans-title>Vavilov Journal of Genetics and Breeding</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2500-3259</issn><publisher><publisher-name>Institute of Cytology and Genetics of Siberian Branch of the RAS</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18699/VJ19.578</article-id><article-id custom-type="elpub" pub-id-type="custom">vavilov-2397</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>БИОТЕХНОЛОГИЯ В ПОСТГЕНОМНУЮ ЭРУ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>MEDICAL GENETICS</subject></subj-group></article-categories><title-group><article-title>Полиморфизм генов липидного обмена в некоторых популяциях Южной и Восточной Сибири</article-title><trans-title-group xml:lang="en"><trans-title>Polymorphism of lipid exchange genes in some populations of South and East Siberia</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5547-8189</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Табиханова</surname><given-names>Л. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Tabikhanova</surname><given-names>L. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Новосибирск</p></bio><bio xml:lang="en"><p>Novosibirsk</p></bio><email xlink:type="simple">tabikhan@bionet.nsc.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7602-1156</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Осипова</surname><given-names>Л. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Osipova</surname><given-names>L. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Новосибирск</p></bio><bio xml:lang="en"><p>Novosibirsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Воронина</surname><given-names>Е. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Voronina</surname><given-names>E. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Новосибирск</p></bio><bio xml:lang="en"><p>Novosibirsk</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Брагин</surname><given-names>А. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Bragin</surname><given-names>A. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Новосибирск</p></bio><bio xml:lang="en"><p>Novosibirsk</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Филипенко</surname><given-names>М. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Filipenko</surname><given-names>M. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Новосибирск</p></bio><bio xml:lang="en"><p>Novosibirsk</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук; Новосибирский национальный исследовательский государственный университет<country>Россия</country></aff><aff xml:lang="en">Institute of Cytology and Genetics, SB RAS; Novosibirsk State University<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук; Новосибирский национальный исследовательский государственный университет<country>Россия</country></aff><aff xml:lang="en">Institute of Chemical Biology and Fundamental Medicine, SB RAS; Novosibirsk State University<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">Новосибирский национальный исследовательский государственный университет<country>Россия</country></aff><aff xml:lang="en">Novosibirsk State University<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>09</day><month>01</month><year>2020</year></pub-date><volume>23</volume><issue>8</issue><fpage>1011</fpage><lpage>1019</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Табиханова Л.Э., Осипова Л.П., Воронина Е.Н., Брагин А.О., Филипенко М.Л., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Табиханова Л.Э., Осипова Л.П., Воронина Е.Н., Брагин А.О., Филипенко М.Л.</copyright-holder><copyright-holder xml:lang="en">Tabikhanova L.E., Osipova L.P., Voronina E.N., Bragin A.O., Filipenko M.L.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vavilov.elpub.ru/jour/article/view/2397">https://vavilov.elpub.ru/jour/article/view/2397</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>буряты</kwd><kwd>телеуты</kwd><kwd>русские Восточной Сибири</kwd><kwd>метисы</kwd><kwd>ПЦР в режиме реального времени</kwd><kwd>липидный обмен</kwd><kwd>генетический полиморфизм</kwd><kwd>CETP (rs5882)</kwd><kwd>LPL (rs328)</kwd><kwd>FTO (rs8050136)</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Buryats</kwd><kwd>Teleuts</kwd><kwd>Russians of Eastern Siberia</kwd><kwd>mixed origin</kwd><kwd>real-time PCR</kwd><kwd>lipid metabolism</kwd><kwd>genetic polymorphism</kwd><kwd>CETP (rs5882)</kwd><kwd>LPL (rs328)</kwd><kwd>FTO (rs8050136)</kwd></kwd-group><funding-group xml:lang="ru"><funding-statement>The work was supported by the Russian Scientific Foundation, project 19-15-00219: “The study of genetic determinants of multifactorial diseases in the indigenous peoples of Siberia”. The authors thank T.M. Karafet, PhD, D.V. Lichman, PhD, N.A. Vavilova, N.A. Moletotova, S.S. Sangaev, PhD, and A.O. Likhacheva for their contribution to scientific expeditions and technical assistance.</funding-statement></funding-group><funding-group xml:lang="en"><funding-statement>The work was supported by the Russian Scientific Foundation, project 19-15-00219: “The study of genetic determinants of multifactorial diseases in the indigenous peoples of Siberia”. The authors thank T.M. Karafet, PhD, D.V. Lichman, PhD, N.A. Vavilova, N.A. Moletotova, S.S. Sangaev, PhD, and A.O. Likhacheva for their contribution to scientific expeditions and technical assistance.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Babenko V.N., Babenko R.O., Gamieldien G., Markel A.L. FTO haplotyping underlines high obesity risk for European populations. BMC Med. Genomics. 2019;12(2):46. DOI 10.1186/s12920­019­0491­x.</mixed-citation><mixed-citation xml:lang="en">Babenko V.N., Babenko R.O., Gamieldien G., Markel A.L. FTO haplotyping underlines high obesity risk for European populations. BMC Med. Genomics. 2019;12(2):46. DOI 10.1186/s12920­019­0491­x.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Bairova T.A., Dolgikh V.V., Kolesnikova L.I., Pervushina O.A. Nutriciogenetics and risk factors of cardiovascular disease: associated research in Eastern Siberia populations. Byulleten’ VSNTs SO RAMN = Bulletin ESSC SB RAMS. 2013;4(92):87­92. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Bairova T.A., Dolgikh V.V., Kolesnikova L.I., Pervushina O.A. Nutriciogenetics and risk factors of cardiovascular disease: associated research in Eastern Siberia populations. Byulleten’ VSNTs SO RAMN = Bulletin ESSC SB RAMS. 2013;4(92):87­92. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Bardymova T.P., Protasov K.V., Donirova O.S., Tsyretorova S.S., Berezina M.V. Ethnic features of myocardial infarction and diabetes mellitus in patients of the Buryat population. Abstracts from the VII Russian Diabetology Congress “Diabetes mellitus in the 21st century: time to unite efforts”, 2015 Feb. 24–27. Moscow, 2015;121. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Bardymova T.P., Protasov K.V., Donirova O.S., Tsyretorova S.S., Berezina M.V. Ethnic features of myocardial infarction and diabetes mellitus in patients of the Buryat population. Abstracts from the VII Russian Diabetology Congress “Diabetes mellitus in the 21st century: time to unite efforts”, 2015 Feb. 24–27. Moscow, 2015;121. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Cahua­Pablo J.A., Cruz M., Méndez­Palacios A., AntúnezOrtiz D.L., Vences­Velázquez A., Alarcón­Romero L.C. Parra E.J., Tello­Flores V.A., Leyva­Vázquez M.A., Valladares­Salgado A., Pérez­Macedonio C.P., Flores­Alfaro E. Polymorphisms in the LPL and CETP genes and haplotype in the ESR1 gene are associated with metabolic syndrome in women from Southwestern Mexico. Int. J. Mol. Sci. 2015;16:21539­21554. DOI 10.3390/ijms160921539.</mixed-citation><mixed-citation xml:lang="en">Cahua­Pablo J.A., Cruz M., Méndez­Palacios A., AntúnezOrtiz D.L., Vences­Velázquez A., Alarcón­Romero L.C. Parra E.J., Tello­Flores V.A., Leyva­Vázquez M.A., Valladares­Salgado A., Pérez­Macedonio C.P., Flores­Alfaro E. Polymorphisms in the LPL and CETP genes and haplotype in the ESR1 gene are associated with metabolic syndrome in women from Southwestern Mexico. Int. J. Mol. Sci. 2015;16:21539­21554. DOI 10.3390/ijms160921539.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Chen B., Li Z., Chen J., Ji J., Shen J., Xu Y., Zhao Y., Liu D., Shen Y., Zhang W., Shen J., Wang Y., Shi Y. Association of fat mass and obesity­associated and retinitis pigmentosa guanosine triphosphatase (GTPase) regulator­interacting protein­1 like polymorphisms with body mass index in Chinese women. Endocr. J. 2018;65(7):783­791. DOI 10.1507/endocrj.EJ17­0554.</mixed-citation><mixed-citation xml:lang="en">Chen B., Li Z., Chen J., Ji J., Shen J., Xu Y., Zhao Y., Liu D., Shen Y., Zhang W., Shen J., Wang Y., Shi Y. Association of fat mass and obesity­associated and retinitis pigmentosa guanosine triphosphatase (GTPase) regulator­interacting protein­1 like polymorphisms with body mass index in Chinese women. Endocr. J. 2018;65(7):783­791. DOI 10.1507/endocrj.EJ17­0554.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Chen J.J., Li Y.M., Zou W.Y., Fu J.L. Relationships between CETP genetic polymorphisms and Alzheimer’s disease risk: a meta­analysis. DNA Cell Biol. 2014;33(11):807­815. DOI 10.1089/dna.2013.2265.</mixed-citation><mixed-citation xml:lang="en">Chen J.J., Li Y.M., Zou W.Y., Fu J.L. Relationships between CETP genetic polymorphisms and Alzheimer’s disease risk: a meta­analysis. DNA Cell Biol. 2014;33(11):807­815. DOI 10.1089/dna.2013.2265.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Cyrus C., Vatte C., Al-Nafie A., Chathoth S., Al-Ali R., AlShehri A., Akhtar M.S., Almansori M., Al­Muhanna F., Keating B., Al­Ali A. The impact of common polymorphisms in CETP and ABCA1 genes with the risk of coronary artery disease in Saudi Arabians. Hum. Genomics. 2016;10(8). DOI 10.1186/s40246­016­0065­3.</mixed-citation><mixed-citation xml:lang="en">Cyrus C., Vatte C., Al-Nafie A., Chathoth S., Al-Ali R., AlShehri A., Akhtar M.S., Almansori M., Al­Muhanna F., Keating B., Al­Ali A. The impact of common polymorphisms in CETP and ABCA1 genes with the risk of coronary artery disease in Saudi Arabians. Hum. Genomics. 2016;10(8). DOI 10.1186/s40246­016­0065­3.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Darenskaya M.A. Features of metabolic reactions in indigenous and migrant populations of Northern Russia and Siberia. Byulleten’ VSNTs SO RAMN = Bulletin ESSC SB RAMS. 2014;2(96):97­103. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Darenskaya M.A. Features of metabolic reactions in indigenous and migrant populations of Northern Russia and Siberia. Byulleten’ VSNTs SO RAMN = Bulletin ESSC SB RAMS. 2014;2(96):97­103. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Hallmark B., Karafet T.M., Hsieh P.H., Osipova L.P., Watkins J.C., Hammer M.F. Genomic evidence of local adaptation to climate and diet in indigenous Siberians. Mol. Biol. Evol. 2018;36(2):315­327. DOI 10.1093/molbev/msy211.</mixed-citation><mixed-citation xml:lang="en">Hallmark B., Karafet T.M., Hsieh P.H., Osipova L.P., Watkins J.C., Hammer M.F. Genomic evidence of local adaptation to climate and diet in indigenous Siberians. Mol. Biol. Evol. 2018;36(2):315­327. DOI 10.1093/molbev/msy211.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Hosseini­Esfahani F., Esfandiar Z., Mirmiran P., Daneshpour M.S., Ghanbarian A., Azizi F. The interaction of cholesteryl ester transfer protein gene variations and diet on changes in serum lipid profiles. Eur. J. Clin. Nutr. 2019; 73:1291­1298. DOI 10.1038/s41430­019­0397­x.</mixed-citation><mixed-citation xml:lang="en">Hosseini­Esfahani F., Esfandiar Z., Mirmiran P., Daneshpour M.S., Ghanbarian A., Azizi F. The interaction of cholesteryl ester transfer protein gene variations and diet on changes in serum lipid profiles. Eur. J. Clin. Nutr. 2019; 73:1291­1298. DOI 10.1038/s41430­019­0397­x.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Hsieh P.H., Hallmark B., Watkins J.C., Karafet T.M., Osipova L.P., Gutenkunst R.N., Hammer M.F. Exome sequencing provides evidence of polygenic adaptation to a fat­rich animal diet in indigenous Siberian populations. Mol. Biol. Evol. 2017;34(11):2913­2926. DOI 10.1093/molbev/msx226.</mixed-citation><mixed-citation xml:lang="en">Hsieh P.H., Hallmark B., Watkins J.C., Karafet T.M., Osipova L.P., Gutenkunst R.N., Hammer M.F. Exome sequencing provides evidence of polygenic adaptation to a fat­rich animal diet in indigenous Siberian populations. Mol. Biol. Evol. 2017;34(11):2913­2926. DOI 10.1093/molbev/msx226.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Koch N.V., Lifschitz G.I., Voronina E.N. Approaches to the lipid metabolism genes polymorphism analysis in screening for atherosclerosis risk factors. Rossiyskiy Kardiologicheskiy Zhurnal = Russian Journal of Cardiology. 2014;10(114):53­-57. DOI 10.15829/1560­4071­2014­10­53­57. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Koch N.V., Lifschitz G.I., Voronina E.N. Approaches to the lipid metabolism genes polymorphism analysis in screening for atherosclerosis risk factors. Rossiyskiy Kardiologicheskiy Zhurnal = Russian Journal of Cardiology. 2014;10(114):53­-57. DOI 10.15829/1560­4071­2014­10­53­57. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Kudryavtseva E.A., Voronina E.N., Lifshits G.I., Krapivina N.A., Tsvetovskaya G.A., Filipenko M.L. No influence of polymorphic variants of genes INSIG2, FTO, GNB3 on the severity of obesity in patients with metabolic syndrome. Vestnik Novosibirskogo Gosudarstvennogo Universiteta. Seriya: Biologiya, klinicheskaya meditsina = Bulleten of Novosibirsk State University. Ser.: Biology, clinical medicine. 2010;8(3):32­39. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Kudryavtseva E.A., Voronina E.N., Lifshits G.I., Krapivina N.A., Tsvetovskaya G.A., Filipenko M.L. No influence of polymorphic variants of genes INSIG2, FTO, GNB3 on the severity of obesity in patients with metabolic syndrome. Vestnik Novosibirskogo Gosudarstvennogo Universiteta. Seriya: Biologiya, klinicheskaya meditsina = Bulleten of Novosibirsk State University. Ser.: Biology, clinical medicine. 2010;8(3):32­39. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Lyudinina A.Yu., Potolitsyna N.N., Solonin Yu.G., Osadchuk L.V., Gutorova N.V., Petrova P.G., Troev I.P., Ostobunaev V.V., Boyko E.R. Lipid profile in men of Komi and Yakut ethnic groups with overweight and obesity. Ekologiya Cheloveka = Human Ecology. 2014;1:13­19. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Lyudinina A.Yu., Potolitsyna N.N., Solonin Yu.G., Osadchuk L.V., Gutorova N.V., Petrova P.G., Troev I.P., Ostobunaev V.V., Boyko E.R. Lipid profile in men of Komi and Yakut ethnic groups with overweight and obesity. Ekologiya Cheloveka = Human Ecology. 2014;1:13­19. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Oteva E.A., Maslennikov A.V., Nikolaeva A.A., Osipova L.P., Evseeva O.L., Sherental’ I.S., Filimonova T.A., Pikovskaja N.V. Features of serum lipid composition in northern Selkups. Terapevticheskiy Arkhiv = Therapeutic Archive. 1993;65(1):21­24. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Oteva E.A., Maslennikov A.V., Nikolaeva A.A., Osipova L.P., Evseeva O.L., Sherental’ I.S., Filimonova T.A., Pikovskaja N.V. Features of serum lipid composition in northern Selkups. Terapevticheskiy Arkhiv = Therapeutic Archive. 1993;65(1):21­24. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Ovsyannikova O.V., Podkhomutnikov V.M., Kolbasko A.V., Luzina F.A., Gus’kova E.V. Cardiovascular disease in rural Kuzbass aborigines – Teleut. Rossiyskiy Kardiologicheskiy Zhurnal = Russian Journal of Cardiology. 2007;12(6):59­62. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Ovsyannikova O.V., Podkhomutnikov V.M., Kolbasko A.V., Luzina F.A., Gus’kova E.V. Cardiovascular disease in rural Kuzbass aborigines – Teleut. Rossiyskiy Kardiologicheskiy Zhurnal = Russian Journal of Cardiology. 2007;12(6):59­62. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Panin L.E. Energy Aspects of Adaptation. Leningrad, 1978. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Panin L.E. Energy Aspects of Adaptation. Leningrad, 1978. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Park S.L., Cheng I., Pendergrass S.A., Kucharska­Newton A.M., Lim U., Ambite J.L., Caberto C.P., Monroe K.R., Schumacher F., Hindorff L.A., Oetjens M.T., Wilson S., Goodloe R.J., Love S.A., Henderson B.E., Kolonel L.N., Haiman C.A., Crawford D.C., North K.E., Heiss G., Ritchie M.D., Wilkens L.R., Le Marchand L. Association of the FTO obesity risk variant rs8050136 with percentage of energy intake from fat in multiple racial/ethnic populations. Am. J. Epidemiol. 2013;178(5):780­790. DOI 10.1093/aje/kwt028.</mixed-citation><mixed-citation xml:lang="en">Park S.L., Cheng I., Pendergrass S.A., Kucharska­Newton A.M., Lim U., Ambite J.L., Caberto C.P., Monroe K.R., Schumacher F., Hindorff L.A., Oetjens M.T., Wilson S., Goodloe R.J., Love S.A., Henderson B.E., Kolonel L.N., Haiman C.A., Crawford D.C., North K.E., Heiss G., Ritchie M.D., Wilkens L.R., Le Marchand L. Association of the FTO obesity risk variant rs8050136 with percentage of energy intake from fat in multiple racial/ethnic populations. Am. J. Epidemiol. 2013;178(5):780­790. DOI 10.1093/aje/kwt028.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Polyakov L.M., Rozumenko A.A., Osipova L.P., Kunitsyn V.G., Goltsova T.V. Serum lipid spectrum of indigenous and alien population of Yamalo­Nenets Autonomous Okrug. Sibirskiy Nauchnyy Meditsinskiy Zhurnal = The Siberian Scientific Medical Journal. 2015;35(6):66­69. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Polyakov L.M., Rozumenko A.A., Osipova L.P., Kunitsyn V.G., Goltsova T.V. Serum lipid spectrum of indigenous and alien population of Yamalo­Nenets Autonomous Okrug. Sibirskiy Nauchnyy Meditsinskiy Zhurnal = The Siberian Scientific Medical Journal. 2015;35(6):66­69. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Ren L., Ren X. Meta­analyses of four polymorphisms of lipoprotein lipase associated with the risk of Alzheimer’s disease. Neurosci. Lett. 2016;619:73­78. DOI 10.1016/j.neulet.2016.03.021.</mixed-citation><mixed-citation xml:lang="en">Ren L., Ren X. Meta­analyses of four polymorphisms of lipoprotein lipase associated with the risk of Alzheimer’s disease. Neurosci. Lett. 2016;619:73­78. DOI 10.1016/j.neulet.2016.03.021.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Sagoo G.S., Tatt I., Salanti G., Butterworth A.S., Sarwar N., Maarle M., Jukema J.W., Wiman B., Kastelein J.J., Bennet A.M., Faire U., Danesh J., Higgins J.P. Seven lipoprotein lipase gene polymorphisms, lipid fractions, and coronary disease: a huge association review and meta­analysis. Am. J. Epidemiol. 2008;168(11):1233­1246. DOI 10.1093/aje/kwn235.</mixed-citation><mixed-citation xml:lang="en">Sagoo G.S., Tatt I., Salanti G., Butterworth A.S., Sarwar N., Maarle M., Jukema J.W., Wiman B., Kastelein J.J., Bennet A.M., Faire U., Danesh J., Higgins J.P. Seven lipoprotein lipase gene polymorphisms, lipid fractions, and coronary disease: a huge association review and meta­analysis. Am. J. Epidemiol. 2008;168(11):1233­1246. DOI 10.1093/aje/kwn235.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Salminen L.E., Schofield P.R., Pierce K.D., Luo X., Zhao Y., Laidlaw D.H., Cabeen R.P., Conturo T.E., Lane E.M., Heaps J.M., Bolzenius J.D., Baker L.M., Cooley S.A., Scott S., Cagle L.M., Paul R.H. Genetic markers of cholesterol transport and gray matter diffusion: a preliminary study of the CETP I405V polymorphism. J. Neural. Transm. 2015;122:1581­1592. DOI 10.1007/s00702­015­1434­0.</mixed-citation><mixed-citation xml:lang="en">Salminen L.E., Schofield P.R., Pierce K.D., Luo X., Zhao Y., Laidlaw D.H., Cabeen R.P., Conturo T.E., Lane E.M., Heaps J.M., Bolzenius J.D., Baker L.M., Cooley S.A., Scott S., Cagle L.M., Paul R.H. Genetic markers of cholesterol transport and gray matter diffusion: a preliminary study of the CETP I405V polymorphism. J. Neural. Transm. 2015;122:1581­1592. DOI 10.1007/s00702­015­1434­0.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Sanders A.E., Wang C., Katz M., Derby C.A., Barzilai N., Ozelius L., Lipton R.B. Association of a functional polymorphism in the cholesteryl ester transfer protein (CETP) gene with memory decline and incidence of dementia. JAMA. 2010;303(2):150­158. DOI 10.1001/jama.2009.1988.</mixed-citation><mixed-citation xml:lang="en">Sanders A.E., Wang C., Katz M., Derby C.A., Barzilai N., Ozelius L., Lipton R.B. Association of a functional polymorphism in the cholesteryl ester transfer protein (CETP) gene with memory decline and incidence of dementia. JAMA. 2010;303(2):150­158. DOI 10.1001/jama.2009.1988.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Semenova N.V., Madaeva I.M., Darenskaya M.A., Gavrilova O.A., Zhambalova R.M., Kolesnikova L.I. Lipid profile in menopausal women of two ethnic groups. Acta Biomedica Scientifica. 2018; 3(3):93-98. DOI 10.29413/ABS.2018­3.3.14. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Semenova N.V., Madaeva I.M., Darenskaya M.A., Gavrilova O.A., Zhambalova R.M., Kolesnikova L.I. Lipid profile in menopausal women of two ethnic groups. Acta Biomedica Scientifica. 2018; 3(3):93-98. DOI 10.29413/ABS.2018­3.3.14. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Sevostyanova Ye.V. Some features of human lipid and carbohydrate metabolism in the North. Byulleten’ Sibirskoy Meditsiny = Bulletin of Siberian Medicine. 2013;12(1):93­-100. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Sevostyanova Ye.V. Some features of human lipid and carbohydrate metabolism in the North. Byulleten’ Sibirskoy Meditsiny = Bulletin of Siberian Medicine. 2013;12(1):93­-100. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Shatwan I.M., Minihane A.M., Williams C.M., Lovegrove J.A., Jackson K.G., Vimaleswaran K.S. Impact of lipoprotein lipase gene polymorphism, S447X, on postprandial triacylglycerol and glucose response to sequential meal ingestion. Int. J. Mol. Sci. 2016;17(3):397. DOI 10.3390/ijms17030397.</mixed-citation><mixed-citation xml:lang="en">Shatwan I.M., Minihane A.M., Williams C.M., Lovegrove J.A., Jackson K.G., Vimaleswaran K.S. Impact of lipoprotein lipase gene polymorphism, S447X, on postprandial triacylglycerol and glucose response to sequential meal ingestion. Int. J. Mol. Sci. 2016;17(3):397. DOI 10.3390/ijms17030397.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Suplotova L.A., Vakhromeeva K.A., Belchikova L.N., Nosikov V.V. Evalaution of association of genetic markers with type 2 diabetes in Russian population. Meditsinskaya Nauka i Obrazovanie Urala = Medical Science and Education of Ural. 2014;4:51­57. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Suplotova L.A., Vakhromeeva K.A., Belchikova L.N., Nosikov V.V. Evalaution of association of genetic markers with type 2 diabetes in Russian population. Meditsinskaya Nauka i Obrazovanie Urala = Medical Science and Education of Ural. 2014;4:51­57. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Tabikhanova L.E., Osipova L.P., Churkina T.V., Voronina E.N., Filipenko M.L. Genetic polymorphism of CYP1A1 and CYP2D6 in populations of Buryats, Teleuts and Russians of Eastern Siberia. Vavilovskii Zhurnal Genetiki i Selektsii = Vavilov Journal of Genetics and Breeding. 2018a;22(2):205­211. DOI 10.18699/VJ18.348. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Tabikhanova L.E., Osipova L.P., Churkina T.V., Voronina E.N., Filipenko M.L. Genetic polymorphism of CYP1A1 and CYP2D6 in populations of Buryats, Teleuts and Russians of Eastern Siberia. Vavilovskii Zhurnal Genetiki i Selektsii = Vavilov Journal of Genetics and Breeding. 2018a;22(2):205­211. DOI 10.18699/VJ18.348. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Tabikhanova L.E., Osipova L.P., Churkina T.V., Voronina E.N., Filipenko M.L. Genetic polymorphism of F2, F5 and VKORC1 in populations of Buryats, Teleuts and Russians of Eastern Siberia. Molekulyarnaya Meditsina = Molecular Medicine. 2018b;16(3):31­36. DOI 10.29296/249994902018­03­06. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Tabikhanova L.E., Osipova L.P., Churkina T.V., Voronina E.N., Filipenko M.L. Genetic polymorphism of F2, F5 and VKORC1 in populations of Buryats, Teleuts and Russians of Eastern Siberia. Molekulyarnaya Meditsina = Molecular Medicine. 2018b;16(3):31­36. DOI 10.29296/249994902018­03­06. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Tang W., Apostol G., Schreiner P.J., Jacobs D.R., Boerwinkle E., Fornage M. Associations of lipoprotein lipase gene polymorphisms with longitudinal plasma lipid trends in young adults: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. Circ. Cardiovasc. Genet. 2010;3(2):179­186. DOI 10.1161/CIRCGENETICS.109.913426.</mixed-citation><mixed-citation xml:lang="en">Tang W., Apostol G., Schreiner P.J., Jacobs D.R., Boerwinkle E., Fornage M. Associations of lipoprotein lipase gene polymorphisms with longitudinal plasma lipid trends in young adults: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. Circ. Cardiovasc. Genet. 2010;3(2):179­186. DOI 10.1161/CIRCGENETICS.109.913426.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Teran-Garcıa M., Despres J.P., Tremblay A., Bouchard C. Effects of cholesterol ester transfer protein (CETP) gene on adiposity in response to long­term overfeeding. Atherosclerosis. 2008;196:455­460.</mixed-citation><mixed-citation xml:lang="en">Teran-Garcıa M., Despres J.P., Tremblay A., Bouchard C. Effects of cholesterol ester transfer protein (CETP) gene on adiposity in response to long­term overfeeding. Atherosclerosis. 2008;196:455­460.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">The 1000 Genomes Project Consortium. An integrated map of genetic variation from 1,092 human genomes. Nature. 2012;491(7422):56­65. DOI 10.1038/nature11632.</mixed-citation><mixed-citation xml:lang="en">The 1000 Genomes Project Consortium. An integrated map of genetic variation from 1,092 human genomes. Nature. 2012;491(7422):56­65. DOI 10.1038/nature11632.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Thompson А., Angelantonio E., Sarwar N., Erqou S., Saleheen D., Dullaart R., Keavney B., Ye Z., Danesh J. Association of cholesteryl ester transfer protein genotypes with CETP mass and activity, lipid levels, and coronary risk. JAMA. 2008;299(23):2777­2788. DOI 10.1001/jama.299.23.2777.</mixed-citation><mixed-citation xml:lang="en">Thompson А., Angelantonio E., Sarwar N., Erqou S., Saleheen D., Dullaart R., Keavney B., Ye Z., Danesh J. Association of cholesteryl ester transfer protein genotypes with CETP mass and activity, lipid levels, and coronary risk. JAMA. 2008;299(23):2777­2788. DOI 10.1001/jama.299.23.2777.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Tsygankova D.P., Mulerova T.A., Ogarkov M.Yu., Mikhalina E.V., Saarela E.Yu., Kazachek Ya.V., Kuzmina A.A., Barbarash O.L. Indicators of lipid metabolism in the inhabitants of Mountain Shoria: ethnic peculiarities and the impact of living conditions. Ateroskleroz i Dislipidemii = The Journal of Atherosclerosis and Dyslipidemias. 2017;1(26):68­76. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Tsygankova D.P., Mulerova T.A., Ogarkov M.Yu., Mikhalina E.V., Saarela E.Yu., Kazachek Ya.V., Kuzmina A.A., Barbarash O.L. Indicators of lipid metabolism in the inhabitants of Mountain Shoria: ethnic peculiarities and the impact of living conditions. Ateroskleroz i Dislipidemii = The Journal of Atherosclerosis and Dyslipidemias. 2017;1(26):68­76. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Webster R.J., Warrington N.M., Weedon M.N., Hattersley A.T., McCaskie P.A., Beilby J.P., Palmer L.J., Frayling T.M. The association of common genetic variants in the APOA5, LPL and GCK genes with longitudinal changes in metabolic and cardiovascular traits. Diabetologia. 2009;52:106­114. DOI 10.1007/s00125­008­1175­9.</mixed-citation><mixed-citation xml:lang="en">Webster R.J., Warrington N.M., Weedon M.N., Hattersley A.T., McCaskie P.A., Beilby J.P., Palmer L.J., Frayling T.M. The association of common genetic variants in the APOA5, LPL and GCK genes with longitudinal changes in metabolic and cardiovascular traits. Diabetologia. 2009;52:106­114. DOI 10.1007/s00125­008­1175­9.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Yang Y., Liu B., Xia W., Yan J., Liu H.Y., Hu L., Liu S.M. FTO genotype and type 2 diabetes mellitus: spatial analysis and meta­analysis of 62 case­control studies from different regions. Genes. 2017;8(2):70. DOI 10.3390/genes8020070.</mixed-citation><mixed-citation xml:lang="en">Yang Y., Liu B., Xia W., Yan J., Liu H.Y., Hu L., Liu S.M. FTO genotype and type 2 diabetes mellitus: spatial analysis and meta­analysis of 62 case­control studies from different regions. Genes. 2017;8(2):70. DOI 10.3390/genes8020070.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Yu L., Shulman J.M., Chibnik L., Leurgans S., Schneider J.A., Jager P.L., Bennett D.A. The CETP I405V polymorphism is associated with an increased risk of Alzheimer’s disease. Aging Cell. 2012;11(2):228­233. DOI 10.1111/j.14749726.2011.00777.x.</mixed-citation><mixed-citation xml:lang="en">Yu L., Shulman J.M., Chibnik L., Leurgans S., Schneider J.A., Jager P.L., Bennett D.A. The CETP I405V polymorphism is associated with an increased risk of Alzheimer’s disease. Aging Cell. 2012;11(2):228­233. DOI 10.1111/j.14749726.2011.00777.x.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
