vavilovВавиловский журнал генетики и селекцииVavilov Journal of Genetics and Breeding2500-3259Institute of Cytology and Genetics of Siberian Branch of the RAS10.18699/VJ20.646vavilov-2719Research ArticleГЕНЕТИКА ЧЕЛОВЕКАHUMAN GENETICSГенетические маркеры о распространении древних морских охотников в ПриохотьеGenetic markers on the distribution of ancient marine hunters in Priokhotyehttps://orcid.org/0000-0002-0304-0652МалярчукБ. А.MalyarchukB. A.malyarchuk@ibpn.ruИнститут биологических проблем Севера Дальневосточного отделения Российской академии наукРоссияInstitute of Biological Problems of the North of the Far-East Branch of the Russian Academy of SciencesRussian Federation202028082020245539544Copyright © Малярчук Б.А., 20202020Малярчук Б.А.Malyarchuk B.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://vavilov.elpub.ru/jour/article/view/2719

Представлен обзор сведений о генетическом полиморфизме современного и древнего населения Севера Азии и Америки с целью реконструкции истории миграций древних морских охотников в Охотоморском регионе. Проанализированы данные о полиморфизме митохондриальной ДНК и распространенности «арктической» мутации – варианта rs80356779-A гена CPT1A. Известно, что «арктический» вариант гена CPT1A с высокой частотой распространен в современных популяциях эскимосов, чукчей, коряков и других народов Охотоморского региона, хозяйственный уклад которых связан с морским зверобойным промыслом. Согласно палеогеномным данным, самые ранние находки «арктического» варианта гена CPT1A обнаружены у гренландских и канадских палеоэскимосов (4 тыс. лет назад), представителей токаревской культуры Северного Приохотья (3 тыс. лет назад) и носителей культуры позднего дзёмона острова Хоккайдо (3.5–3.8 тыс. лет назад). Результаты анализа позволили выявить несколько миграционных событий, связанных с распространением морских охотников в Охотоморском регионе. Самая поздняя миграция, оставившая следы у носителей культуры эпи-дзёмон (2.0–2.5 тыс. лет назад), привнесла с севера Приохотья на Хоккайдо и соседние территории Приамурья митохондриальную гаплогруппу G1b и «арктический» вариант гена CPT1A. Следы более ранней миграции, также привнесшей «арктическую» мутацию, зарегистрированы у населения позднего дзёмона Хоккайдо (3.5–3.8 тыс. лет назад). Проведен филогенетический анализ митохондриальных геномов, относящихся к редкой гаплогруппе C1a, встречающейся у населения Дальнего Востока и Японии, но в филогенетическом отношении родственной C1-гаплогруппам американских индейцев. Результаты показали, что дивергенция митохондриальных линий в пределах гаплогруппы C1a происходила в диапазоне от 7.9 до 6.6 тыс. лет назад, а возраст японской ветви гаплогруппы C1a составляет ~5.2 тыс. лет. Пока неизвестно, связана ли эта миграция с распространением «арктического» варианта гена CPT1A или же присутствие C1a-гаплотипов у населения островов Японии маркирует собой еще один, более ранний, эпизод миграционной истории, связывающей население северо-западной Пацифики и Северной Америки.

This is a review of studies on the genetic polymorphism of modern and ancient populations of the north of Asia and America, with the aim of reconstructing the history of migrations of ancient marine hunters in the Okhotsk Sea region. The data on mitochondrial DNA polymorphism and the “Arctic” mutation distribution – the rs80356779-A variant of the CPT1A gene – were analyzed. It is known that the “Arctic” variant of the CPT1A gene is widely distributed in modern populations of the Eskimos, Chukchis, Koryaks, and other peoples of the Okhotsk Sea region, whose economic structure is associated with marine hunting. According to paleogenomic data, the earliest cases of the “Arctic” variant of the CPT1A gene were found in the Greenland and Canadian Paleoeskimos (4 thousand years ago), among representatives of the Tokarev culture of the Northern Priokhotye (3 thousand years ago), and among the bearers of the culture of the late Jomon of Hokkaido (3.5–3.8 thousand years ago). The results of the analysis revealed several migration events associated with the spread of marine hunters in the Okhotsk Sea region. The latest migration, which left traces on bearers of the Epi-Jomon culture (2.0–2.5 thousand years ago), introduced the mitochondrial haplogroup G1b and the “Arctic” variant of the CPT1A gene from the north of Priokhotye to Hokkaido and neighboring territories of the Amur Region. Traces of earlier migration, which also brought the “Arctic” mutation, were recorded in the Hokkaido population of the late Jomon period (3.5–3.8 thousand years ago). A phylogenetic analysis of mitochondrial genomes belonging to the rare haplogroup C1a, found in populations of the Far East and Japan, but phylogenetically related to the C1-haplogroups of the Amerindians, was carried out. The results of the analysis showed that the divergence of mitochondrial lineages within the C1a haplogroup occurred in the range from 7.9 to 6.6 thousand years ago, and the age of the Japanese branch of the C1a haplogroup is approximately 5.2 thousand years. It is not yet known whether this migration is associated with the spread of the “Arctic” variant of the CPT1A gene or the presence of C1a haplotypes in the population of the Japanese islands marks another, earlier, episode of the migration history linking the populations of Northwest Pacific and North America.

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The authors declare that there are no conflicts of interest present.