vavilovВавиловский журнал генетики и селекцииVavilov Journal of Genetics and Breeding2500-3259Institute of Cytology and Genetics of Siberian Branch of the RASvavilov-288Research ArticleСтатьиArticlesЭНХАНСЕРЫ ТРАНСЛЯЦИИ ДЛЯ ГЕННОЙ ИНЖЕНЕРИИ РАСТЕНИЙTRANSLATIONAL ENHANCERS FOR PLANT GENE ENGINEERINGКочетовА. В.KochetovA. V.ak@bionet.nsc.ruФилипенкоЕ. А.FilipenkoE. A.ak@bionet.nsc.ruСмирноваО. Г.SmirnovaO. G.ak@bionet.nsc.ruШумныйВ. К.ShumnyV. K.ak@bionet.nsc.ruФедеральное государственное бюджетное учреждение науки Институт цитологии и генетики Сибирского отделения Российской академии наук, Новосибирск, Россия Новосибирский национальный исследовательский государственный университет, Новосибирск, РоссияРоссияInstitute of Cytology and Genetics SB RAS, Novosibirsk, Russia Novosibirsk National Research State University, Novosibirsk, RussiaRussian FederationФедеральное государственное бюджетное научное учреждение «Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук», Новосибирск, РоссияРоссияInstitute of Cytology and Genetics SB RAS, Novosibirsk, RussiaRussian Federation201418012015184/1610617Copyright © Кочетов А.В., Филипенко Е.А., Смирнова О.Г., Шумный В.К., 20152015Кочетов А.В., Филипенко Е.А., Смирнова О.Г., Шумный В.К.Kochetov A.V., Filipenko E.A., Smirnova O.G., Shumny V.K.This work is licensed under a Creative Commons Attribution 4.0 License.https://vavilov.elpub.ru/jour/article/view/288

Трансгенные растения широко используются для проведения фундаментальных и прикладных исследований. Эффективная экспрессия трансгенов зависит от правильного выбора служебных элементов при планировании структуры генетической конструкции, в частности, важное значение имеет структура 5′-нетранслируемого района, влияющая на эффективность инициации трансляции мРНК. В статье рассмотрены характеристики 5′-НТП, определяющие эффективность трансляции мРНК в клетках растений, а также различные трансляционные энхансеры.

Transgenic plants are often used in both fundamental and applied research. It is well known that transgene expression strongly depends on the genetic construct design. In particular, 5′-UTR is an important element, as it influences mRNA translation efficiency and the protein synthesis rate. The review considers 5′-UTR features controlling translation efficiency in plant cells and some useful translational enhancers.

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The authors declare that there are no conflicts of interest present.