vavilovВавиловский журнал генетики и селекцииVavilov Journal of Genetics and Breeding2500-3259Institute of Cytology and Genetics of Siberian Branch of the RAS10.18699/VJ21.066vavilov-3117Research ArticleБИОИНФОРМАТИКА И СИСТЕМНАЯ КОМПЬЮТЕРНАЯ БИОЛОГИЯBIOINFORMATICS AND COMPUTATIONAL SYSTEMS BIOLOGYКомплексный анализ влияния аллельного полиморфизма 5-HTTLPR на поведенческие и нейрофизиологические показатели исполнительного контроля у людей из разных этнических групп в СибириComprehensive analysis of the 5-HTTLPR allelic polymorphism effect on behavioral and neurophysiological indicators of executive control in people from different ethnic groups in Siberiahttps://orcid.org/0000-0002-3514-2901СавостьяновА. Н.SavostyanovA. N.

Новосибирск

Novosibirsk

a-sav@mail.ruБазовкинаД. В.BazovkinaD. V.

Новосибирск

Novosibirsk

https://orcid.org/0000-0003-3138-381XЛашинС. А.LashinS. A.

Новосибирск

Novosibirsk

ТаможниковС. С.TamozhnikovS. S.

Новосибирск

Novosibirsk

СапрыгинА. Е.SapryginA. E.

Новосибирск

Novosibirsk

АстаховаТ. Н.AstakhovaT. N.

Новосибирск

Novosibirsk

Кавай-оолУ. Н.Kavai-oolU. N.

Кызыл, Республика Тыва

Kyzyl, Tyva Republic

БорисоваН. В.BorisovaN. V.

Якутск

Yakutsk, Sakha Republic

КарповаА. Г.KarpovaA. G.

Якутск

Yakutsk, Sakha Republic

Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук; Научно-исследовательский институт нейронаук и медицины; Новосибирский национальный исследовательский государственный университетРоссияInstitute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences; Scientific-Research Institute of Neuroscience and MedicineRussian FederationФедеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наукРоссияInstitute of Cytology and Genetics of the Siberian Branch of the Russian Academy of SciencesRussian FederationФедеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук; Новосибирский национальный исследовательский государственный университетРоссияInstitute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences; Novosibirsk State UniversityRussian FederationНаучно-исследовательский институт нейронаук и медициныРоссияScientific-Research Institute of Neuroscience and MedicineRussian FederationФедеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук; Научно-исследовательский институт нейронаук и медициныРоссияInstitute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences; Scientific-Research Institute of Neuroscience and MedicineRussian FederationНовосибирский национальный исследовательский государственный университетРоссияNovosibirsk State UniversityRussian FederationТувинский научный центрРоссияTuvan Scientific CenterRussian FederationСеверо-Восточный федеральный университет им. М.К. АммосоваРоссияM.K. Ammosov North-Eastern Federal UniversityRussian Federation202110092021255593602Copyright © Савостьянов А.Н., Базовкина Д.В., Лашин С.А., Таможников С.С., Сапрыгин А.Е., Астахова Т.Н., Кавай-оол У.Н., Борисова Н.В., Карпова А.Г., 20212021Савостьянов А.Н., Базовкина Д.В., Лашин С.А., Таможников С.С., Сапрыгин А.Е., Астахова Т.Н., Кавай-оол У.Н., Борисова Н.В., Карпова А.Г.Savostyanov A.N., Bazovkina D.V., Lashin S.A., Tamozhnikov S.S., Saprygin A.E., Astakhova T.N., Kavai-ool U.N., Borisova N.V., Karpova A.G.This work is licensed under a Creative Commons Attribution 4.0 License.https://vavilov.elpub.ru/jour/article/view/3117

Аллельный полиморфизм гена транспортера серотонина 5-HTTLPR рассматривается как один из факторов, определяющих генетическую предрасположенность человека к развитию широкого ряда аффективных нарушений, включая депрессию. Во многих исследованиях было показано, что климатические и социальные условия жизни людей могут оказать существенное влияние на взаимосвязь 5-HTTLPR с риском депрессии. Стоп-сигнал парадигма (ССП) – это экспериментальный метод, позволяющий оценить способности человека к контролю своего поведения в условиях изменяющейся внешней среды. В ССП эксперименте испытуемый должен либо быстро нажимать на одну из нескольких кнопок после появления целевых стимулов, либо подавлять уже начатое движение, если после целевого стимула следует запрещающий сигнал. В представленной работе исследуются ассоциации полиморфизма 5-HTTLPR с оценками уровня личностной тревожности, а также поведенческими и нейрофизиологическими (электроэнцефалограмма, ЭЭГ) показателями способности к контролю двигательных реакций в ССП у представителей трех этно-региональных групп – здоровых европеоидов из г. Новосибирска, монголоидных групп коренного населения Республики Тыва и Республики Саха (Якутия). Целью исследования было сопоставление генетических, этнографических и психологических эффектов на способность индивида к контролю моторных ответов. Амплитуда премоторного пика вызванного потенциала использована в качестве нейрофизиологического маркера готовности человека к выполнению целенаправленных действий. Выявлено, что частота встречаемости аллеля S полиморфизма 5-HTTLPR достоверно выше для обеих монголоидных групп в сравнении с европеоидной. Генотип S/S ассоциирован с повышенным уровнем личностной тревожности и одновременно с лучшей способностью к контролю движений в условиях ССП эксперимента. Уровень тревожности, пол испытуемых, этническая принадлежность и аллельный полиморфизм 5-HTTLPR оказывают статистически достоверное влияние на амплитуду премоторного потенциала готовности, регистрируемого в условиях ССП в лобных и теменно-затылочных областях коры. Наши данные подтверждают гипотезу, что генотип S/S полиморфизма 5-HTTLPR может быть ассоциирован с большей успешностью адаптации к климатическим условиям, связанным с высоким риском для жизни, в сравнении с генотипами L/L и L/S.

The allelic polymorphism of the serotonin transporter’s gene 5-HTTLPR is considered as one of the factors determining an individual genetic predisposition to the development of a wide range of affective disorders, including depression. Many studies have shown that the climatic and social conditions of people’s life can have a significant impact on the connections of 5-HTTLPR with the risk of depression. The stop-signal paradigm (SSP) is an experimental method allowing evaluating an individual ability to the self-control of behavior in a changing environment. In the SSP experiment, a subject should either press one of several buttons quickly after the appearance of the target stimuli or suppress the already started movement if an inhibitory signal follows the target stimulus. The aim of this study is a research of associations between the allelic the 5-HTTLPR polymorphism and the individual scores of the personal anxiety level, as well as the behavioral and neurophysiological indicators of the ability to self-control over motor reactions in the SSP. The study was conducted among people from three ethno-regional groups: healthy Caucasoids from Novosibirsk, the Mongoloid groups of the indigenous population of the Tuva Republic and Sakha Republic (Yakutia). Genetic, ethnographic, and psychological influences on an individual’s ability to control motor responses were compared. The amplitude of the premotor peak of the evoked brain potential was used as a neurophysiological marker of the person’s readiness to the execution of target-directed activity. It was revealed that the frequency of the S-allele polymorphism 5-HTTLPR was significantly higher for both mongoloid groups compared to the Caucasoids. The S/S genotype was associated with an increased level of personal anxiety and at the same time with a better ability to the self-control of behavior in the SSP experiment. Anxiety level, participants’ sex, ethnicity, and allelic polymorphism 5-HTTLPR had a statistically significant effect on the amplitude of the premotor readiness potential recorded under the SSP conditions in the frontal and parietal-occipital cortical regions. Our data support the hypothesis that the S/S genotype of the 5-HTTLPR polymorphism may be associated with more success in adapting to the climatic conditions connected with high life risk in comparison to L/L and L/S genotypes.

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The authors declare that there are no conflicts of interest present.