vavilovВавиловский журнал генетики и селекцииVavilov Journal of Genetics and Breeding2500-3259Institute of Cytology and Genetics of Siberian Branch of the RASvavilov-315Research ArticleСтатьиArticlesАНАЛИЗ ВЗАИМОДЕЙСТВИЯ АЛЛЕЛЕЙ ГЕНОВ ЛИПИДНОГО ОБМЕНА ПРИ ДИСЛИПИДЕМИИANALYSIS OF THE INTERACTION OF LIPID METABOLISM ALLELES IN DYSLIPIDEMIAНиколаевИ. В.NikolaevI. V.obg_bspu@mail.ruМулюковаР. В.MulyukovaR. V.КаюмоваЛ. Р.KayumovaL. R.ВоробьеваЕ. В.VorobievаE. V.ГорбуноваВ. Ю.GorbunovaV. Yu.Федеральное государственное бюджетноеобразовательное учреждение высшего профессионального образования «Башкирский государственный педагогический университет им. М. Акмуллы»РоссияAkmulla Bashkir State Pedagogical University, Ufa, RussiaRussian FederationФедеральное государственное бюджетное образовательное учреждение высшего профессионального образования «Башкирский государственный педагогический университет им. М. Акмуллы»РоссияAkmulla Bashkir State Pedagogical University, Ufa, RussiaRussian Federation201421012015184/2856866Copyright © Николаев И.В., Мулюкова Р.В., Каюмова Л.Р., Воробьева Е.В., Горбунова В.Ю., 20152015Николаев И.В., Мулюкова Р.В., Каюмова Л.Р., Воробьева Е.В., Горбунова В.Ю.Nikolaev I.V., Mulyukova R.V., Kayumova L.R., Vorobievа E.V., Gorbunova V.Y.This work is licensed under a Creative Commons Attribution 4.0 License.https://vavilov.elpub.ru/jour/article/view/315

В клинической практике часто используют показатели липидного обмена. К его нарушениям (дислипидемии) относят повышение уровня общего холестерина (ОХС), триглицеридов (ТГ), а также изменение ряда других показателей, являющихся результатом нарушения синтеза, транспорта и расщепления липопротеинов. Клиническая значимость метаболических нарушений, объединенных рамками дислипидемии, ассоциируется, в первую очередь, с высоким риском развития сердечно-сосудистых заболеваний, сахарного диабета второго типа и ожирения. Исследована связь SNP следующих генов: G-2548A в промоторной области гена лептина (LEP), A223G в 4-м экзоне гена рецептора лептина (LEPR), Т495G в 8-м интроне гена липопротеинлипазы (LPL), C34G в 8-м экзоне гена ядерного рецептора (PPARG), с нарушениями липидного обмена, и показан их кумулятивный эффект в развитии дислипидемии.

Parameters of lipid metabolism in the spectrum of blood serum are the most commonly used indicators in clinical practice. Their disturbances (dyslipidemia) are: elevated levels of total cholesterol and triglycerides, as well as changes of other parameters resulting from aberrations in lipoprotein synthesis, transport and cleavage. The clinical significance of metabolic disorders covered by the term dyslipidemia is associated primarily with high risks of cardiovascular diseases, diabetes mellitus type 2, and obesity. Associations of certain SNPs (G-2548A in the promoter region of the leptin gene (LEP), A223G in exon 4 of the leptin receptor gene (LEPR), T495G in intron 8 in the lipoprotein lipase gene (LPL), and C34G in exon 8 of a nuclear receptor (PPARG)) with disturbed lipid metabolism have been investigated, and their cumulative contribution to the development of dyslipidemia is demonstrated.

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The authors declare that there are no conflicts of interest present.