vavilovВавиловский журнал генетики и селекцииVavilov Journal of Genetics and Breeding2500-3259Institute of Cytology and Genetics of Siberian Branch of the RASvavilov-327Research ArticleСтатьиArticlesМАТЕМАТИЧЕСКАЯ МОДЕЛЬ РЕГУЛЯЦИИ ФИТОГОРМОНАМИ ФОРМИРОВАНИЯ МЕРИСТЕМАТИЧЕСКОЙ ЗОНЫ КОРНЯMATHEMATICAL MODEL OF PHYTOHORMONE REGULATION OF ROOT MERISTEMATIC ZONE FORMATIONЛаврехаВ. В.LavrekhaV. V.vvl@bionet.nsc.ruОмельянчукН. А.OmelyanchukN. A.vvl@bionet.nsc.ruМироноваВ. В.MironovaV. V.vvl@bionet.nsc.ruФедеральное государственное бюджетное научное учреждение «Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук», Новосибирск, РоссияРоссияInstitute of Cytology and Genetics SB RAS, Novosibirsk, RussiaRussian FederationФедеральное государственное бюджетное учреждение науки Институт цитологии и генетики Сибирского отделения Российской академии наук, Новосибирск, Россия Новосибирский национальный исследовательский государственный университет, Новосибирск, РоссияРоссияInstitute of Cytology and Genetics SB RAS, Novosibirsk, Russia Novosibirsk National Research State University, Novosibirsk, RussiaRussian Federation201422012015184/2963972Copyright © Лавреха В.В., Омельянчук Н.А., Миронова В.В., 20152015Лавреха В.В., Омельянчук Н.А., Миронова В.В.Lavrekha V.V., Omelyanchuk N.A., Mironova V.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://vavilov.elpub.ru/jour/article/view/327

Расположенная в кончике корня апикальная меристема растения – один из удобных объектов исследования организации ниши стволовых клеток. В апикальной меристеме корня митотически слабо активные клетки покоящегося центра соседствуют с активно делящимися клетками, которые теряют эту способность на определенном расстоянии от покоящегося центра. Известно, что важную роль в регуляции формирования такой структуры играют фитогормоны ауксин и цитокинин, однако конкретные механизмы поддержания ее в динамике пока неизвестны. В работе предложена математическая модель, которая обобщает экспериментальные данные о распределении ауксина и цитокинина вдоль продольной оси корня и их роли в регуляции клеточного цикла. Минимальный механизм регуляции клеточного цикла ауксином и цитокинином, лежащий в основе модели, позволил продемонстрировать in silico самоорганизацию меристематической зоны корня в градиентах концентраций этих веществ.

The apical meristem located at the root tip of a plant is one of the most convenient objects to study the organization of the stem cell niche. In the root apical meristem, mitotically inactive cells of the quiescent center coexist with intensely dividing cells, which lose this ability at a certain distance from the quiescent center. It is known that plant hormones auxin and cytokinin play an important role in the regulation of this structure formation, but the mechanisms maintaining the dynamics of this structure remain unknown. We propose a mathematical model that summarizes experimental data on the distribution of auxin and cytokinin along the root longitudinal axis and their role in cell cycle regulation.

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The authors declare that there are no conflicts of interest present.