vavilovВавиловский журнал генетики и селекцииVavilov Journal of Genetics and Breeding2500-3259Institute of Cytology and Genetics of Siberian Branch of the RASvavilov-330Research ArticleСтатьиArticlesРЕКОМБИНАНТНЫЕ ШТАММЫ SACCHAROMYCES CEREVISIAE ДЛЯ ПОЛУЧЕНИЯ ЭТАНОЛА ИЗ РАСТИТЕЛЬНОЙ БИОМАССЫRECOMBINANT STRAINS OF SACCHAROMYCES CEREVISIAE FOR ETHANOL PRODUCTION FROM PLANT BIOMASSРозановА. С.RozanovA. S.rozanov@bionet.nsc.ruКотенкоА. В.KotenkoA. V.rozanov@bionet.nsc.ruАкбердинИ. Р.AkberdinI. R.rozanov@bionet.nsc.ruПельтекС. Е.PeltekS. E.rozanov@bionet.nsc.ruФедеральное государственное бюджетное научное учреждение «Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук», Новосибирск, РоссияРоссияInstitute of Cytology and Genetics SB RAS, Novosibirsk, RussiaRussian Federation201422012015184/2989998Copyright © Розанов А.С., Котенко А.В., Акбердин И.Р., Пельтек С.Е., 20152015Розанов А.С., Котенко А.В., Акбердин И.Р., Пельтек С.Е.Rozanov A.S., Kotenko A.V., Akberdin I.R., Peltek S.E.This work is licensed under a Creative Commons Attribution 4.0 License.https://vavilov.elpub.ru/jour/article/view/330

Saccharomyces cerevisiae является наиболее подходящим и используемым организмом для промышленного получения биоэтанола из сахаров, так как дрожжи имеют высокие темпы роста, ферментации и наработки этанола в анаэробных условиях, а также они устойчивы к высоким концентрациям этанола и низким значениям pH. Наиболее перспективным источником сахаров считается лигноцеллюлозная биомасса. Сахара, полученные из лигноцеллюлозной биомассы, являются смесью гексоз и пентоз. Однако используемые штаммы S. cerevisiae слабо приспособлены к сбраживанию пентасахаридов, в связи с чем необходима оптимизация метаболизма существующих в настоящее время продуцентов биоэтанола, направленная на использование пентасахаров. В работе представлен обзор существующих в мире подходов, разработанных для решения этой задачи с помощью рекомбинантных штаммов S. cerevisiae.

Saccharomyces cerevisiae is the most appropriate and the most widely used model organism for industrial production of ethanol from sugars, because yeasts (1) have high rates of growth, fermentation and  biosynthesis of ethanol under anaerobic conditions and (2) are tolerant of high concentrations of ethanol and low pH values. Currently, the most promising source of sugar is lignocellulosic biomass. Sugars derived from it are a mixture of hexoses and pentoses. However, S. cerevisiae strains in current use are poorly adapted to pentasaccharide fermentation. Therefore, it is necessary to optimize the metabolism of currently available bioethanol producers for pentasaccharide consumption. The article presents an overview of existing approaches designed to solve this problem by using recombinant S. cerevisiae strains.

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The authors declare that there are no conflicts of interest present.