vavilovВавиловский журнал генетики и селекцииVavilov Journal of Genetics and Breeding2500-3259Institute of Cytology and Genetics of Siberian Branch of the RAS10.18699/vjgb-26-30vavilov-5039Research ArticleМЕДИЦИНСКАЯ ГЕНЕТИКАMEDICAL GENETICSОсобенности коннективности дефолтной сети мозга в зависимости от полиморфизма гена транспортера серотонина (5-HTTLPR)Features of connectivity of default mode network depending on polymorphism of serotonin transporter gene (5-HTTLPR)БочаровА. В.BocharovA. V.

Новосибирск

Novosibirsk

bocharovav@neuronm.ruСавостьяновА. Н.SavostyanovA. N.

Новосибирск

Novosibirsk

ТаможниковС. С.TamozhnikovS. S.

Новосибирск

Novosibirsk

СапрыгинА. Е.SapryginA. E.

Новосибирск

Novosibirsk

ЛебедкинД. А.LebedkinD. A.

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Novosibirsk

МеркуловаЕ. А.MerkulovaE. A.

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Novosibirsk

КнязевГ. Г.KnyazevG. G.

Новосибирск

Novosibirsk

Научно-исследовательский институт нейронаук и медициныРоссияScientific Research Institute of Neurosciences and MedicineRussian Federation202606042026302267273Copyright © Бочаров А.В., Савостьянов А.Н., Таможников С.С., Сапрыгин А.Е., Лебедкин Д.А., Меркулова Е.А., Князев Г.Г., 20262026Бочаров А.В., Савостьянов А.Н., Таможников С.С., Сапрыгин А.Е., Лебедкин Д.А., Меркулова Е.А., Князев Г.Г.Bocharov A.V., Savostyanov A.N., Tamozhnikov S.S., Saprygin A.E., Lebedkin D.A., Merkulova E.A., Knyazev G.G.This work is licensed under a Creative Commons Attribution 4.0 License.https://vavilov.elpub.ru/jour/article/view/5039

Полиморфизм гена транспортера серотонина имеет большое значение в регуляции серотонинергической системы, влияющей на настроение и регуляцию эмоций и поведения. В исследовании была проведена запись 128-канальной электроэнцефалограммы и взяты образцы буккального эпителия у 53 добровольцев (32 женщины). Аллели La, Lg и S были определены методом полимеразной цепной реакции. Целью работы было изучение особенностей коннективности дефолтной сети мозга, измеренной с помощью электрофизиологических данных состояния покоя, в зависимости от полиморфизма гена транспортера серотонина. Локализация источников биоэлектрической активности коры мозга осуществлялась методом формирователя пучка. Сравнение групп носителей LaLa генотипа и носителей одного из аллелей S или Lg было выполнено с помощью Т-контраста показателей коннективности, рассчитанных между узлами дефолтной сети мозга и остальным мозгом. Обнаружено, что для носителей S или Lg аллеля характерна повышенная коннективность дефолтной сети мозга со зрительной ассоциативной корой и со структурами, образующими задний узел дефолтной сети мозга, а также повышенная коннективность заднего узла дефолтной сети мозга с правой парагиппокампальной извилиной, что может предрасполагать к возникновению и/или поддержанию навязчивых мыслей. У носителей LaLa генотипа по сравнению с носителями S или Lg аллеля была выше коннективность переднего узла дефолтной сети мозга с правой вентромедиальной лобной корой, с медиальной лобной извилиной и с задней поясной корой, являющейся структурой заднего узла дефолтной сети мозга. Также у носителей LaLa генотипа по сравнению с носителями S или Lg аллеля была выше коннективность заднего узла дефолтной сети мозга с кластером, охватывающим правую дорсолатеральную префронтальную кору. Можно предположить, что увеличение коннективности дефолтной сети мозга со структурами мозга (дорсолатеральная и вентромедиальная префронтальная кора), участвующими в процессах когнитивной регуляции, способствует регуляции процессов дефолтной сети мозга, связанных с автобиографическими воспоминаниями.

Serotonin transporter gene polymorphism is important in the regulation of the serotoninergic system that affects mood and the regulation of emotions and behavior. In this study, 128 channel electroencephalogram recordings were performed, and buccal epithelium samples were obtained from 53 volunteers (32 females). La, Lg, and S alleles were identified by polymerase chain reaction. The aim of the study was to investigate the connectivity of the default mode network, measured using resting state electrophysiologic data, depending on the serotonin transporter gene polymorphism. Localization of the sources of bioelectrical activity of the cerebral cortex was performed by the beamformer method. Comparisons of LaLa genotype carriers and S or Lg allele carriers were performed using T-contrast of connectivity indices calculated between the nodes of the default mode network and the rest of the brain. It was found that carriers of the S allele were characterized by increased connectivity of the default mode network with the visual association cortex and with structures forming the posterior node of the default mode network, as well as increased connectivity of the posterior node of the default mode network with the right parahippocampal gyrus, and this pattern of connectivity may predispose to the onset and/or maintenance of intrusive thoughts. Whereas carriers of the LaLa genotype had higher connectivity of the anterior node of the default mode network with the right ventromedial prefrontal cortex, with the medial frontal gyrus, and with the posterior cingulate cortex, which is the structure of the posterior node of the default mode network, compared to carriers of the S or Lg allele. Also, carriers of the LaLa genotype had higher connectivity of the posterior node of the default mode network with the cluster involving the right dorsolateral prefrontal cortex compared to carriers of the S or Lg allele. It could be hypothesized that increased connectivity of the default mode network with brain structures (i. e., dorsolateral and ventromedial prefrontal cortex) involved in cognitive regulation processes may contribute to the regulation of the processes of the default mode network associated with autobiographical memory.

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The authors declare that there are no conflicts of interest present.