vavilovВавиловский журнал генетики и селекцииVavilov Journal of Genetics and Breeding2500-3259Institute of Cytology and Genetics of Siberian Branch of the RAS10.18699/VJ16.173vavilov-697Research ArticleГенетика развития. СИСТЕМАТИЧЕСКИЙ ОБЗОРDevelopmental genetics. SYSTEMATIC REVIEWСистемно-биологический анализ гена WOX5 и его функций в нише стволовых клеток корняSystems biology analysis of the WOX5 gene and its functions in the root stem cell nicheОщепковаЕ. А.OshchepkovaE. A.

Новосибирск

Novosibirsk

ОмельянчукН. А.OmelyanchukN. A.

Новосибирск

Novosibirsk

СавинаМ. С.SavinaM. S.

Новосибирск

Novosibirsk

ПастернакТ.PasternakT.

Фрайбург

Freiburg

КолчановН. А.KolchanovN. A.

Новосибирск

Novosibirsk

ЗемлянскаяЕ. В.ZemlyanskayaE. V.

Новосибирск

Novosibirsk

Федеральное государственное бюджетное научное учреждение «Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук»; Федеральное государственное автономное образовательное учреждение высшего образования «Новосибирский национальный исследовательский государственный университет»РоссияInstitute of Cytology and Genetics SB RAS; Novosibirsk State UniversityRussian FederationИнститут биологии II/ молекулярной физиологии растенийГерманияInstitute of Biology II/Molecular Plant Physiology, Centre for BioSystems Analysis (ZBSA), BIOSS Centre for Biological Signalling Studies, University of FreiburgGermany201625092016204460474Copyright © Ощепкова Е.А., Омельянчук Н.А., Савина М.С., Пастернак Т., Колчанов Н.А., Землянская Е.В., 20162016Ощепкова Е.А., Омельянчук Н.А., Савина М.С., Пастернак Т., Колчанов Н.А., Землянская Е.В.Oshchepkova E.A., Omelyanchuk N.A., Savina M.S., Pasternak T., Kolchanov N.A., Zemlyanskaya E.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://vavilov.elpub.ru/jour/article/view/697

Ген WUSCHEL RELATED HOMEOBOX 5 (WOX5) кодирует транскрипци­онный фактор, который является одним из основных регуляторов поддержания структуры и функционирования ниши стволовых клеток в кончике корня растений. Белок WOX5 экспрессируется в клетках покоящегося центра апикальной меристемы корня, предотвращая дифференцировку прилегающих к нему инициа­лей колумеллы и участвуя наряду с SCR, SHR, PLT1, PLT2 в контроле дифференцировки других инициалей меристемы корня. Однако детали механизмов функционирования этого белка неясны. WOX5 относится к семейству WUSCHEL related homeobox (WOX), родоначальник которого, транскрипционный фактор WUSCHEL (WUS), обеспечивает поддержание ниши стволовых клеток в меристеме побега. Считается, что ген WOX5 дивергировал от общего с WUS предка у древних покрытосеменных, в резуль­тате чего произошла специализация ниш стволовых клеток побега и корня. Однако вопрос дальнейшей дивергенции структуры и функций WOX5 в процессе эволюции цветковых растений изучен слабо. В данном обзоре представлен системнобиологический анализ гена WOX5 с целью выявления особенно­стей его эволюции и механизмов функционирования. Для этого в работе проведен филогенетический анализ 62 аминокислотных последовательностей WOX5 из публично доступных баз данных, обобщены литературные данные о домене экспрессии WOX5 у арабидопсиса и других видов и его функциях в онтогенезе, приведены результаты экспериментов по выявлению первичных и вторичных мишеней этого транскрипционного фактора, а также обсуждены данные о возможных механизмах прямой и непрямой регуляции экспрессии WOX5. В частности, был проведен анализ промоторных областей гена WOX5 у 30 видов растений и были высказаны гипотезы о возможных прямых регуляторах экспрес­сии WOX5 на основании наличия соответствующих потенциаль­ных сайтов связывания в консервативных областях промоторов гена WOX5.

WUSCHEL RELATED HOMEOBOX 5 (WOX5) gene encodes the transcription factor, which is one of the key regulators, maintaining structure and functioning of the stem cell niche in plant root tips. Protein WOX5 is expressed in the quiescent center of the root apical meristem, preventing differentiation of columella initials and altogether with SCR, SHR, PLT1 and PLT2 participating in the control of differentiation of other root meristem initials. However, the details of WOX5 functioning are unclear. The WOX5 protein belongs to WUSCHEL related homeobox (WOX) family, the founder of which is the transcription factor WUSCHEL (WUS) providing maintenance of the stem cell niche in the shoot apical meristem. WOX5 and WUS diverged from a common ancestor at the base of angiosperms, which resulted in a specialization of shoot and root stem cell niches. However, the problem of WOX5 structural and functional divergence during angiosperm evolution was poorly addressed. In this review we present a systems biology analysis of the WOX5 gene to reveal specific features of its evolution and functioning. To this end, we performed a phylogenetic analysis on 62 publicly available WOX5 amino acid sequences, generalized published data about WOX5 expression domain in Arabidopsis and other species and its role in development, integrated the results of experiments on identification of primary and secondary targets for this transcription factor. Data on possible mechanisms of direct and indirect regulation of WOX5 expression were discussed. Particularly, we performed the analysis of WOX5 promoter regions from 30 species. Possible direct regulators of the WOX5 gene expression were proposed based on the presence of putative binding sites for the candidate transcription factors in conserved WOX5 promoter regions.

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The authors declare that there are no conflicts of interest present.