vavilovВавиловский журнал генетики и селекцииVavilov Journal of Genetics and Breeding2500-3259Institute of Cytology and Genetics of Siberian Branch of the RASvavilov-75Research ArticleСтатьиArticlesКОМПЬЮТЕРНЫЙ АНАЛИЗ ВЗАИМОСВЯЗИ АЛЛЕРГЕННОСТИ МИКРООРГАНИЗМОВ И СРЕДЫ ИХ ОБИТАНИЯCOMPUTERIZED ANALYSIS OF THE RELATIONSHIP BETWEEN ALLERGENICITY OF MICROORGANISMS AND THEIR HABITATSБрагинА. О.BraginA. O.ibragim@bionet.nsc.ruДеменковП. С.DemenkovP. S.ibragim@bionet.nsc.ruТийсЕ. С.TiysE. S.ibragim@bionet.nsc.ruХофештадтР.HofestädtR.ИванисенкоВ. А.IvanisenkoV. A.ibragim@bionet.nsc.ruКолчановН. А.KolchanovN. A.ibragim@bionet.nsc.ruФедеральное государственное бюджетное научное учреждение «Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук», Новосибирск, РоссияРоссияInstitute of Cytology and Genetics SB RAS, Novosibirsk, RussiaRussian FederationУниверситет Билефельда, Билефельд, ГерманияГерманияBio-Medical Informatics Department, Bielefeld University, Bielefeld, GermanyGermanyФедеральное государственное бюджетное учреждение науки Институт цитологии и генетики Сибирского отделения Российской академии наук, Новосибирск, Россия Новосибирский национальный исследовательский государственный университет, Новосибирск, Россия НИЦ «Курчатовский институт», Москва, РоссияРоссияInstitute of Cytology and Genetics SB RAS, Novosibirsk, Russia Novosibirsk National Research State University, Novosibirsk, Russia National Research Centre «Kurchatov Institute», Moscow, RussiaRussian Federation201215122014164/1784790Copyright © Брагин А.О., Деменков П.С., Тийс Е.С., Хофештадт Р., Иванисенко В.А., Колчанов Н.А., 20142014Брагин А.О., Деменков П.С., Тийс Е.С., Хофештадт Р., Иванисенко В.А., Колчанов Н.А.Bragin A.O., Demenkov P.S., Tiys E.S., Hofestädt R., Ivanisenko V.A., Kolchanov N.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://vavilov.elpub.ru/jour/article/view/75

В течение 20-го столетия наблюдался стремительный рост числа аллергических заболеваний. На данный момент в индустриальных странах от аллергии страдает значительная часть населения, что делает анализ аллергенных свойств белков важной задачей. Ранее выдвигались предположения, что аллергенность белков зависит от их размера, ферментативных свойств, гомологии с белками человека и т. д. Однако анализ взаимосвязи аллергенности белков и среды обитания организма, к которому принадлежат данные белки, до сих пор не проводился. Нами были предсказаны белки-аллергены из протеомов более 500 видов микроорганизмов. Показано, что количество белков-аллергенов в протеомах микроорганизмов статистически значимо связано с патогенностью, ареалом, температурными условиями среды обитания и потребностью в кислороде этих микроорганизмов.

The prevalence of allergic diseases was rapidly increasing in the 20th century. Currently, many people suffer from allergy in industrial countries. Therefore, analysis of allergenic properties of proteins is an urgent task. The following factors were formerly hypothesized to determine the allergenicity of a protein: size, enzymatic properties, and similarity to human proteins. However, no analysis of the relationship between allergenicity of proteins and the habitat of the organisms producing them has been conducted hitherto. We predict allergenicity of proteins from proteomes of more than 500 species of microorganisms. It is shown that the number of allergenic proteins in the proteomes of microorganisms is significantly associated with their pathogenicity, habitat, temperature conditions of the habitat, and oxygen demand.

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The authors declare that there are no conflicts of interest present.