<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vavilov</journal-id><journal-title-group><journal-title xml:lang="ru">Вавиловский журнал генетики и селекции</journal-title><trans-title-group xml:lang="en"><trans-title>Vavilov Journal of Genetics and Breeding</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2500-3259</issn><publisher><publisher-name>Institute of Cytology and Genetics of Siberian Branch of the RAS</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">vavilov-83</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>BioInfoWF – СИСТЕМА АВТОМАТИЧЕСКОЙ ГЕНЕРАЦИИ WEB-ИНТЕРФЕЙСОВ И WEB-СЕРВИСОВ ДЛЯ БИОИНФОРМАЦИОННЫХ ИССЛЕДОВАНИЙ</article-title><trans-title-group xml:lang="en"><trans-title>BioInfoWF – WEB SERVICES AND WEB INTERFACES GENERATOR FOR BIOINFORMATICS ANALYSIS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Генаев</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Genaev</surname><given-names>M. A.</given-names></name></name-alternatives><email xlink:type="simple">mag@bionet.nsc.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Комышев</surname><given-names>Е. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Komyshev</surname><given-names>E. G.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гунбин</surname><given-names>К. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Gunbin</surname><given-names>K. V.</given-names></name></name-alternatives><email xlink:type="simple">mag@bionet.nsc.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Афонников</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Afonnikov</surname><given-names>D. A.</given-names></name></name-alternatives><email xlink:type="simple">mag@bionet.nsc.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Учреждение Российской академии наук Институт цитологии и генетики Сибирского&#13;
отделения Российской академии наук, Новосибирск, Россия<country>Россия</country></aff><aff xml:lang="en">Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Новосибирский национальный исследовательский государственный университет" (НГУ)<country>Россия</country></aff><aff xml:lang="en">Novosibirsk National Research State University, Novosibirsk, Russia<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">Учреждение Российской академии наук Институт цитологии и генетики Сибирского&#13;
отделения Российской академии наук, Новосибирск, Россия&#13;
Новосибирский национальный исследовательский государственный университет, Новосибирск, Россия<country>Россия</country></aff><aff xml:lang="en">Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia&#13;
Novosibirsk National Research State University, Novosibirsk, Russia<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>15</day><month>12</month><year>2014</year></pub-date><volume>16</volume><issue>4/1</issue><fpage>849</fpage><lpage>857</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Генаев М.А., Комышев Е.Г., Гунбин К.В., Афонников Д.А., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Генаев М.А., Комышев Е.Г., Гунбин К.В., Афонников Д.А.</copyright-holder><copyright-holder xml:lang="en">Genaev M.A., Komyshev E.G., Gunbin K.V., Afonnikov D.A.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vavilov.elpub.ru/jour/article/view/83">https://vavilov.elpub.ru/jour/article/view/83</self-uri><abstract><p>В настоящей работе представлена система BioInfoWF для автоматической генерации Web-интерфейсов и Web-сервисов для вычислительных модулей в области биоинформатики. Для каждого вычислительного модуля, используемого в этой системе, вводится метаописание на языке XML. На основе метаописаний BioInfoWF автоматически генерируют Web-интерфейсы и Web-сервисы, которые в дальнейшем могут использоваться как в различных биоинформационных системах, так и непосредственно в самой системе BioInfoWF. Вычислительные модули в нашей системе могут объединяться в конвейеры, для которых автоматически генерируется пользовательский Web-интерфейс. Разработанный нами инструмент существенно упрощает разработку и публикацию модулей анализа биоинформатических данных в сети, что обеспечивает их доступность для сообществ биологов и биоинформатиков. Система BioInfoWF распространяется под свободной лицензией GNU GPL. Дистрибутив и пользовательская документация системы BioInfoWF доступны на сайте http://bioinfowf.bionet.nsc.ru.</p></abstract><trans-abstract xml:lang="en"><p>The BioinfoWF (Bioinformatics WorkFlow) system for automated generation of Web interface and Web services for bioinformatics programs. Each program module used in the system has metadescription in XML. The metadescriptions are used for automated generation of Web interface and Web services that can be used further in bioinformatics workflows. Computational modules can be organized in workflows. The tool we have developed significantly simplify the design and publication of modules for bioinformatics data analysis via the internet and their availability for scientific communities. The developed system makes is distributed under GNU GPL. The Source codes and documentation for BioinfoWF are available at http://bioinfowf.bionet.nsc.ru.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>биоинформатика</kwd><kwd>интеграция данных</kwd><kwd>конвейерная обработка данных</kwd><kwd>метаописание данных</kwd><kwd>Web-интерфейс</kwd><kwd>Web-сервис</kwd></kwd-group><kwd-group xml:lang="en"><kwd>bioinformatics</kwd><kwd>data integration</kwd><kwd>workflow data processing</kwd><kwd>data metadescription</kwd><kwd>Web interface</kwd><kwd>Web service</kwd></kwd-group><funding-group xml:lang="ru"><funding-statement>Министерство образования и науки РФ</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Гунбин К.В., Генаев М.А., Турнаев И.И., Афонников Д.А. Компьютерная система анализа режимов молекулярной эволюции генов и белков: анализ эволюции циклинов B // Вестн. Томского гос. ун-та. Биология. 2011. 4. С. 175–189.</mixed-citation><mixed-citation xml:lang="en">Гунбин К.В., Генаев М.А., Турнаев И.И., Афонников Д.А. Компьютерная система анализа режимов молекулярной эволюции генов и белков: анализ эволюции циклинов B // Вестн. Томского гос. ун-та. Биология. 2011. 4. С. 175–189.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Bhagat J., Tanoh F., Nzuobontane E. et al. BioCatalogue: a universal catalogue of Web services for the life sciences // Nucl. Acids Res. 2010. V. 38. Р. 689–694.</mixed-citation><mixed-citation xml:lang="en">Bhagat J., Tanoh F., Nzuobontane E. et al. BioCatalogue: a universal catalogue of Web services for the life sciences // Nucl. Acids Res. 2010. V. 38. Р. 689–694.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Deelman E., Gannon D., Shields M., Taylor I. Workfl ows and e-Science: An overview of workfl ow system features and capabilities // Future Generation Computer Systems. 2009. V. 25. Р. 528–540.</mixed-citation><mixed-citation xml:lang="en">Deelman E., Gannon D., Shields M., Taylor I. Workfl ows and e-Science: An overview of workfl ow system features and capabilities // Future Generation Computer Systems. 2009. V. 25. Р. 528–540.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Dereeper A., Guignon V., Blanc G. et al. Phylogeny.fr: robust phylogenetic analysis for the non-specialist // Nucl. Acids Res. 2008. V. 36. Р. 465–469.</mixed-citation><mixed-citation xml:lang="en">Dereeper A., Guignon V., Blanc G. et al. Phylogeny.fr: robust phylogenetic analysis for the non-specialist // Nucl. Acids Res. 2008. V. 36. Р. 465–469.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Fernald G.H., Capriotti E., Daneshjou R. et al. Bioinformatics challenges for personalized medicine // Bioinformatics. 2011. V. 27. Р. 1741–1748.</mixed-citation><mixed-citation xml:lang="en">Fernald G.H., Capriotti E., Daneshjou R. et al. Bioinformatics challenges for personalized medicine // Bioinformatics. 2011. V. 27. Р. 1741–1748.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Goble C.A., Bhagat J., Aleksejevs S. et al. myExperiment: a repository and social network for the sharing of bioinformatics workfl ows // Nucl. Acids Res. 2010. V. 38. Р. 677–682.</mixed-citation><mixed-citation xml:lang="en">Goble C.A., Bhagat J., Aleksejevs S. et al. myExperiment: a repository and social network for the sharing of bioinformatics workfl ows // Nucl. Acids Res. 2010. V. 38. Р. 677–682.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Goecks J., Nekrutenko A., Taylor J., Galaxy: a comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences // Genome Biol. 2010. 11:R86.</mixed-citation><mixed-citation xml:lang="en">Goecks J., Nekrutenko A., Taylor J., Galaxy: a comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences // Genome Biol. 2010. 11:R86.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Gunbin K.V., Suslov V.V., Genaev M.A., Afonnikov D.A. Computer system for analysis of molecular evolution modes (SAMEM): analysis of molecular evolution modes at deep inner branches of the phylogenetic tree // In Silico Biol. 2012. In press.</mixed-citation><mixed-citation xml:lang="en">Gunbin K.V., Suslov V.V., Genaev M.A., Afonnikov D.A. Computer system for analysis of molecular evolution modes (SAMEM): analysis of molecular evolution modes at deep inner branches of the phylogenetic tree // In Silico Biol. 2012. In press.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Gunbin K.V., Suslov V.V., Turnaev I.I. et al. Molecular evolution of cyclin proteins in animals and fungi // BMC Evol. Biol. 2011. V. 11. P. 224.</mixed-citation><mixed-citation xml:lang="en">Gunbin K.V., Suslov V.V., Turnaev I.I. et al. Molecular evolution of cyclin proteins in animals and fungi // BMC Evol. Biol. 2011. V. 11. P. 224.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Hartmann A., Czauderna T., Hoffmann R. et al. HTPheno: an image analysis pipeline for high-throughput plant phenotyping // BMC Bioinformatics. 2011. V. 12. P. 148.</mixed-citation><mixed-citation xml:lang="en">Hartmann A., Czauderna T., Hoffmann R. et al. HTPheno: an image analysis pipeline for high-throughput plant phenotyping // BMC Bioinformatics. 2011. V. 12. P. 148.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Moore J.H., Asselbergs F.W., Williams S.M. Bioinformatics challenges for genome-wide association studies // Bioinformatics. 2010. V. 26. Р. 445–455.</mixed-citation><mixed-citation xml:lang="en">Moore J.H., Asselbergs F.W., Williams S.M. Bioinformatics challenges for genome-wide association studies // Bioinformatics. 2010. V. 26. Р. 445–455.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Oinn T., Addis M., Ferris J. et al. Taverna: a tool for the composition and enactment of bioinformatics workfl ows // Bioinformatics. 2004. V. 20. Р. 3045–3054.</mixed-citation><mixed-citation xml:lang="en">Oinn T., Addis M., Ferris J. et al. Taverna: a tool for the composition and enactment of bioinformatics workfl ows // Bioinformatics. 2004. V. 20. Р. 3045–3054.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Pop M., Salzberg S.L. Bioinformatics challenges of new sequencing technology // Trends Genet. 2008. V. 24. Р. 142–149.</mixed-citation><mixed-citation xml:lang="en">Pop M., Salzberg S.L. Bioinformatics challenges of new sequencing technology // Trends Genet. 2008. V. 24. Р. 142–149.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Pupko T., Pe’er I., Hasegawa M. et al. A branch-and-bound algorithm for the inference of ancestral amino-acid sequences when the replacement rate varies among sites: Application to the evolution of fi ve gene families // Bioinformatics. 2002. V. 18. Р. 1116–1123.</mixed-citation><mixed-citation xml:lang="en">Pupko T., Pe’er I., Hasegawa M. et al. A branch-and-bound algorithm for the inference of ancestral amino-acid sequences when the replacement rate varies among sites: Application to the evolution of fi ve gene families // Bioinformatics. 2002. V. 18. Р. 1116–1123.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Sánchez R., Serra F., Tárraga J. et al. Phylemon 2.0: a suite of Web-tools for molecular evolution, phylogenetics, phylogenomics and hypotheses testing // Nucl. Acids Res. 2011. V. 39. Р. 470–474.</mixed-citation><mixed-citation xml:lang="en">Sánchez R., Serra F., Tárraga J. et al. Phylemon 2.0: a suite of Web-tools for molecular evolution, phylogenetics, phylogenomics and hypotheses testing // Nucl. Acids Res. 2011. V. 39. Р. 470–474.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Smith N.G. Are radical and conservative substitution rates useful statistics in molecular evolution? // J. Mol. Evol. 2003. V. 57. Р. 467–478.</mixed-citation><mixed-citation xml:lang="en">Smith N.G. Are radical and conservative substitution rates useful statistics in molecular evolution? // J. Mol. Evol. 2003. V. 57. Р. 467–478.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang J. Rates of conservative and radical nonsynonymous nucleotide substitutions in mammalian nuclear genes // J. Mol. Evol. 2000. V. 50. Nо. 1. P. 56–68.</mixed-citation><mixed-citation xml:lang="en">Zhang J. Rates of conservative and radical nonsynonymous nucleotide substitutions in mammalian nuclear genes // J. Mol. Evol. 2000. V. 50. Nо. 1. P. 56–68.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
