vavilovВавиловский журнал генетики и селекцииVavilov Journal of Genetics and Breeding2500-3259Institute of Cytology and Genetics of Siberian Branch of the RASvavilov-85Research ArticleСтатьиArticles3С-МЕТОДЫ В ИССЛЕДОВАНИЯХ ПРОСТРАНСТВЕННОЙ ОРГАНИЗАЦИИ ГЕНОМА3C-BASED METHODS FOR 3D GENOME ORGANIZATION ANALYSISБатуллинН. Р.BattulinN. R.battulin@bionet.nsc.ruФишманВ. С.FishmanV. S.battulin@bionet.nsc.ruОрловЮ. Л.OrlovYu. L.battulin@bionet.nsc.ruМензоровА. Г.MenzorovA. G.battulin@bionet.nsc.ruАфонниковД. А.AfonnikovD. A.battulin@bionet.nsc.ruСеровО. Л.SerovO. L.battulin@bionet.nsc.ruФедеральное государственное бюджетное учреждение науки Институт цитологии и генетики Сибирского отделения Российской академии наук, Новосибирск, Россия Новосибирский национальный исследовательский государственный университет, Новосибирск, РоссияРоссияInstitute of Cytology and Genetics SB RAS, Novosibirsk, Russia Novosibirsk State University, Novosibirsk, RussiaRussian Federation201215122014164/2872878Copyright © Батуллин Н.Р., Фишман В.С., Орлов Ю.Л., Мензоров А.Г., Афонников Д.А., Серов О.Л., 20142014Батуллин Н.Р., Фишман В.С., Орлов Ю.Л., Мензоров А.Г., Афонников Д.А., Серов О.Л.Battulin N.R., Fishman V.S., Orlov Y.L., Menzorov A.G., Afonnikov D.A., Serov O.L.This work is licensed under a Creative Commons Attribution 4.0 License.https://vavilov.elpub.ru/jour/article/view/85

Пространственная трехмерная организация генома эукариот играет важную роль в функционировании ядерного материала. До недавнего времени единственной возможностью исследования пространственной организации генома в ядре клеток было использование методов световой и электронной микроскопии. Появление метода захвата конформации хромосом (chromosome conformation capture, 3С) позволило изучать хромосомные контакты, используя только молекулярно-биологические подходы. На сегодняшний день на основе 3С разработано целое семейство методов реконструкции пространственной организации генома.

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The authors declare that there are no conflicts of interest present.