Гены и свет: много лет спустя
https://doi.org/10.18699/VJ17.265
Аннотация
Статья написана к 100-летию со дня рождения Д.К. Беляева и затрагивает его работы, посвященные влиянию фотопериодических условий на размножение и эмбриональное развитие млекопитающих. В качестве одной из моделей в этих исследованиях была использована грузинская белая мутация у лисиц (W G). В контрольных условиях способность гомозигот по этой мутации успешно пройти имплантацию резко снижена. Экспериментальное удлинение светового дня для беременных самок из W G/w × W G/w скрещиваний ведет к значительному возрастанию частоты мутантных гомозигот в потомстве. В статье предпринята попытка анализа результатов этой работы в свете современных данных. Грузинская белая мутация, вероятно, обусловливает снижение экспрессии гена KIT. Рассмотрение молекулярных и клеточных взаимодействий с участием белка KIT, его лиганда KITLG и их влияния на развитие бластоцист указывает на возможность замедленного развития W G/W G бластоцист и, как следствие, опоздание к началу имплантации. Изменение фотопериодических условий может через стимулирование развития W G/W G гомозиготных бластоцист, замедление роста трофобласта у зрелых бластоцист, повышение готовности эндометрия и вероятную задержку начала имплантации создавать более благоприятные обстоятельства для успешной имплантации W G/W G бластоцист.
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