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Вавиловский журнал генетики и селекции

Расширенный поиск

Церебральные органоиды – перспективная модель в клеточных технологиях

https://doi.org/10.18699/VJ18.344

Полный текст:

Аннотация

Развитие головного мозга человека представляет собой сложный многоэтапный процесс, включающий образование различных типов нейральных клеток и их взаимодействия. Многие фундаментальные механизмы нейрогенеза установлены благодаря изучению модельных животных. Однако значительные структурные различия головного мозга по сравнению с другими животными не позволяют рассмотреть все аспекты формирования головного мозга у человека, которые могут играть решающую роль для развития его уникальных когнитивных способностей. Новая технология трехмерных церебральных органоидов открывает исследователям уникальную возможность моделировать ранние этапы нейрогенеза человека. В обзоре рассматриваются технология получения трехмерных церебральных органоидов, примеры ее успешного внедрения в фундаментальные и прикладные исследования, имеющиеся проблемы, а также перспективы ее развития.

Об авторе

Т. А. Шнайдер
Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук
Россия
Новосибирск


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