Исследование эффектов грибов Cantharellus cibarius на трематоду O. felineus и на хозяина паразита-инбредных мышей C57BL/6

Описторхоз - опасное паразитарное заболевание, вызываемое трематодами семейства Opistorchiidae, в том числе видом Opisthorchis felineus, распространенным на территории Российской Федерации и Западной Европы. В наше время остается актуальным поиск новых препаратов для лечения описторхоза с максимальным противопаразитарным и минимальным побочным действием. В работе исследованы потенциальные антигельминтные эффекты экстракта грибов Лисичка обыкновенная (Cantharellus cibarius). В экспериментах in vitro показано, что при повышении концентрации экстракта C. cibarius (10-1000 мкг/мл) подвижность и выживаемость ювенильных особей O. felineus значительно снижается. В исследованиях in vivo экстракт C. cibarius, вводимый мышам инбредной линии C57BL/6 в первые сутки после инфицирования, приводил к снижению количества гельминтов в желчных протоках печени, оцениваемому через шесть недель после инфицирования. В другой серии экспериментов введение экстракта в течение семи дней мышам с пятинедельным сроком инфицирования не оказывало антигельминтного эффекта. В обоих случаях состояние хозяина паразита, оцениваемое по ряду физиологических и биохимических параметров, не ухудшалось, что говорит об отсутствии какого-либо негативного действия экстракта C. cibarius. Полученные результаты свидетельствуют в пользу возможных антигельминтных свойств экстракта C. cibarius при применении на стадии эксцистирования личинок паразита.

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