MODELS OF STEM CELL NICHE structure REGULATION IN SHOOT APICAL MERISTEM
Abstract
The experimental data obtained to date provided grounds for certain concepts of the stem cell niche regulation in shoot apical meristem. Mathematical modeling is used for checking their consistency and coherence with experimental evidence. In this paper, we summarize mathematical models of stem cell niche regulation offered by different authors, analyze the experimental base and working hypotheses formalized in these models, and identify methodological differences in the approaches to the construction of these models.
About the Authors
U. S. ZubairovaRussian Federation
S. V. Nikolaev
Russian Federation
References
1. Николаев С.В., Зубаирова У.С., Пененко А.В. и др. Модель регуляции структуры ниши стволовых клеток в апикальной меристеме побега Arabidopsis thaliana // Докл. АН. 2013. Т. 451. № 5. С. 336–338.
2. Николаев С.В., Зубаирова У.С., Фадеев С.И. и др. Исследование одномерной модели регуляции размеров возобновительной зоны в биологической ткани с учетом деления клеток // Сиб. журн. индустр. математики. 2010. Т. 13. Вып. 4(44). С. 70–82.
3. Николаев С.В., Колчанов Н.А., Фадеев С.И. и др. Исследование одномерной модели регуляции размеров возобновительной зоны в биологической ткани // Вычисл. технол. 2006. Т. 11. Вып. 2. С. 67–81.
4. Николаев С.В., Пененко А.В., Лавреха В.В. и др. Модельное изучение роли белков СLV1, CLV2, CLV3 и WUS в регуляции структуры апикальной меристемы побега // Онтогенез. 2007. Т. 38. Вып. 6. С. 457–462.
5. Чуб В.В., Синюшин А.А. Фасциация цветка и побега: от феноменологии к построению моделей преобразования апикальной меристемы // Физиол. растений. 2012. Т. 59. Вып. 4. С. 1–17.
6. Barton M.K. Twenty years on: the inner workings of the shoot apical meristem, a developmental dynamo // Dev. Biol. 2010. V. 341. P. 95–113.
7. Brand U., Fletcher J.C., Hobe M. et al. Dependence of stem cell fate in Arabidopsis on a feedback loop regulated by CLV3 activity // Science. 2000. V. 289. P. 617–619.
8. Brand U., Grunewald M., Hobe M., Simon R. Regulation of CLV3 expression by two homeobox genes in Arabidopsis // Plant Physiol. 2002. V. 129. P. 565–575.
9. Brand U., Hobe M., Simon R. Functional domains in plant shoot meristems // Bioessays. 2001. V. 23. P. 134–141.
10. Bowman J.L., Eshed Y. Formation and maintenance of the shoot apical meristem // Trends Plant Sci. 2000. V. 5. P. 110–115.
11. Chickarmane V.S., Gordon S.P., Tarr P.T. et al. Cytokinin signaling as a positional cue for patterning the apical–basal axis of the growing Arabidopsis shoot meristem // Proc. Natl Acad. Sci. USA. 2012. V. 109. Nо. 10. P. 4002–4007.
12. Fujita H., Toyokura K., Okada K., Kawaguchi M. Reactiondiffusion pattern in shoot apical meristem of plants // PLoS ONE. 2011. V. 6. e18243.
13. Geier F., Lohmann J.U., Gerstung M. et al. A quantitative and dynamic model for plant stem cell regulation // PLoS ONE. 2008. V. 3. e3553.
14. Gordon S.P., Chickarmane V.S., Ohno C., Meyerowitz E.M. Multiple feedback loops through cytokinin signaling control stem cell number within the Arabidopsis shoot meristem // Proc. Natl Acad. Sci. USA. 2009. V. 106. P. 16529–16534.
15. Gross-Hardt R., Laux T. Stem cell regulation in the shoot meristem // J. Cell Sci. 2003. V. 116. P. 1659–1666.
16. Hohm T., Zitzler E., Simon R. A dynamic model for stem cell homeostasis and patterning in Arabidopsis meristems // PLoS ONE. 2010. V. 5. e9189.
17. Jönsson H., Gruel J., Krupinski P., Troein C. On evaluating models in computational morphodynamics // Curr. Opin. Plant Biol. 2012. V. 15. P. 103–110.
18. Jönsson H., Heisler M., Reddy G.V. et al. Modeling the organization of the WUSCHEL expression domain in the shoot apical meristem // Bioinformatics. 2005. V. 21 (Suppl. 1) P. i232–i240.
19. Jönsson H., Shapiro B., Meyerowitz E., Mjolsness E. Signaling in multicellular models of plant development // On Growth Form and Computers / Ed. S. Kumar, P. Bentley. L.: Acad. Press, 2003. P. 156–161.
20. Kerstetter R.A., Bollman K., Taylor R.A. et al. KANADI regulates organ polarity in Arabidopsis // Nature. 2001. V. 411. P. 706–709.
21. Kwiatkowska D. Structural integration at the shoot apical meristem: models, measurements, and experiments // Am. J. Bot. 2004. V. 91. P. 1277–1293.
22. Lenhard M., Laux T. Stem cell homeostasis in the Arabidopsis shoot meristem is regulated by intercellular movement of CLAVATA3 and its sequestration by CLAVATA1 // Development. 2003. V. 130. P. 3163–3173.
23. Mjolsness E., Sharp D.H., Reinitz J. A connectionist model of development // J. Theor. Biol. 1991. V. 152. P. 429–453.
24. Newman I.V. Pattern in the meristems of vascular plants. III. Pursuing the patterns in the apical meristem where no cell is a permanent cell // J. Linn. Soc. (Botany). 1965. V. 59. P. 185–214.
25. Ogawa M., Shinohara H., Sakagami Y., Matsubayashi Y. Arabidopsis CLV3 peptide directly binds CLV1 ectodomain // Science. 2008. V. 319. P. 294.
26. Reddy V.G., Meyerowitz E.M. Stem-cell homeostasis and growth dynamics can be uncoupled in the Arabidopsis shoot apex // Science. 2005. V. 310. Nо. 5748. P. 663–667.
27. Rojo E., Sharma V.K., Kovaleva V. et al. CLV3 is localized to the extracellular space, where it activates the Arabidopsis CLAVATA stem cell signaling pathway // Plant Cell. 2002. V. 14. P. 969–977.
28. Sablowski R. Plant stem cell niches: from signalling to execution // Curr. Opin. Plant Biol. 2011. V. 14. P. 4–9.
29. Sahlin P., Melke P., Jцnsson H. Models of sequestration and receptor cross-talk for explaining multiple mutants in plant stem cell regulation // BMC Syst. Biol. 2011. V. 5. 2.
30. Schoof H., Lenhard M., Haecker A. et al. The stem cell population of Arabidopsis shoot meristems in maintained by a regulatory loop between the CLAVATA and WUSCHEL genes // Cell. 2000. V. 100 P. 635–644.
31. Sharma V.K., Carles C., Fletcher J.C. Maintenance of stem cell populations in plants // Proc. Natl Acad. Sci. USA. 2003. V. 100 (Suppl 1) P. 11823–11829.
32. Traas J., Doonan J.H. Cellular basis of shoot apical meristem development // Int. Rev. Cytol. 2001. V. 208. P. 161–206.
33. Williams L., Fletcher J.C. Stem cell regulation in the Arabidopsis shoot apical meristem // Curr. Opin. Plant Biol. 2005. V. 8. P. 582–586.
34. Yadav R.K., Girke T., Pasala S. et al. Gene expression map of the arabidopsis shoot apical meristem stem cell niche // Proc. Natl Acad. Sci. USA. 2009. V. 106. P. 4941–4946.
35. Yadav R.K., Perales M., Gruel J. et al. WUSCHEL protein movement mediates stem cell homeostasis in the Arabidopsis shoot apex // Genes Dev. 2011. V. 25. P. 2025–2030.
36. Yadav R.K., Perales M., Gruel J. et al. Plant stem cell maintenance involves direct transcriptional repression of differentiation program // Mol. Syst. Biol. 2013. V. 9. Р. 654.