Polymorphism of lipid exchange genes in some populations of South and East Siberia
https://doi.org/10.18699/VJ19.578
Abstract
Lipid metabolism disorders underlie the pathogenesis of a number of diseases. Indigenous peoples of Siberia have a specific genetically determined type of metabolism supporting such lipid blood parameters that favor increased consumption (in comparison with Caucasians) of animal products. At the same time, indigenous Siberian ethnic groups are less susceptible to metabolic diseases. The objective of the presented study was to investigate the allele frequencies of lipid metabolism genes in indigenous populations of Siberia to identify the ethnic features of allele frequency distribution for polymorphic variants in genes CETP (G1264A, rs5882), LPL (C1791G, rs328) and FTO (C83401A, rs8050136) in the samples taken from Buryats, Teleuts and Russians of Eastern Siberia, and to compare them with data on world populations. Samples of the Eastern (N = 132) and Western (N = 278) Buryats, Teleuts (N = 120), Russians (N = 122) and persons of mixed Buryat-Russian origin (N = 56) were genotyped by real-time PCR using competitive TaqMan-probes. The obtained results have for the first time demonstrated that the CETP and FTO allele frequencies in the Buryat samples are intermediate between European and East Asian populations. Significantly lower incidence of the obesity-assossiated 83401A allele of the FTO gene has been shown in Buryats, compared with Russians, which is consistent with lower susceptibility of the indigenous ethnic groups to metabolic disorders. There have been no population differences in the distribution of LPL gene polymorphic variants associated with dyslipidemia, which means they probably do not contribute to the ethnic characteristics of the lipid profile. The intermediate frequencies of the CETP 1264G and FTO 83401A alleles found in the metis group demonstrate that the metabolic disorders associated with these variants can be rather expected in the descendants of mixed marriages than among Buryats. It has also been demonstrated that Teleuts differ by FTO 83401A allele frequency from some of the European groups and have the lowest detected frequency of the allele CETP 1264G associated with the favorable lipid blood parameters.
Keywords
Buryats,
Teleuts,
Russians of Eastern Siberia,
mixed origin,
real-time PCR,
lipid metabolism,
genetic polymorphism,
CETP (rs5882),
LPL (rs328),
FTO (rs8050136)
Supporting agencies: The work was supported by the Russian Scientific Foundation, project 19-15-00219: “The study of genetic determinants of multifactorial diseases in the indigenous peoples of Siberia”. The authors thank T.M. Karafet, PhD, D.V. Lichman, PhD, N.A. Vavilova, N.A. Moletotova, S.S. Sangaev, PhD, and A.O. Likhacheva for their contribution to scientific expeditions and technical assistance.
About the Authors
L. E. Tabikhanova
Institute of Cytology and Genetics, SB RAS; Novosibirsk State University
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
L. P. Osipova
Institute of Cytology and Genetics, SB RAS; Novosibirsk State University
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
E. N. Voronina
Institute of Chemical Biology and Fundamental Medicine, SB RAS; Novosibirsk State University
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
A. O. Bragin
Novosibirsk State University
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
M. L. Filipenko
Institute of Chemical Biology and Fundamental Medicine, SB RAS; Novosibirsk State University
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
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