ПОДАВЛЕНИЕ РЕПЛИКАЦИИ СУБГЕНОМНОГО РНК РЕПЛИКОНА ВИРУСА ГЕПАТИТА С ИНГИБИТОРОМ NS3 ПРОТЕАЗЫ SCH 503034 В Huh-7 КЛЕТКАХ: СТОХАСТИЧЕСКАЯ МОДЕЛЬ

Вирус гепатита С (ВГС) вызывает опасное заболевание печени, часто сопровождающееся циррозом и гепатоклеточной карциномой. Против ВГС до сих пор нет эффективной терапии. Для предсказания эффективности действия новых потенциальных лекарств, направленных против ВГС, актуально применение математического моделирования. Впервые предложена стохастическая модель репликации субгеномного РНК репликона ВГС в Huh-7 клетках в присутствии ингибитора NS3 протеазы ВГС SCH 503034. Модель описывает экспериментально полученные кинетики подавления вирусной РНК в присутствии разных концентраций SCH 503034 и может применяться для разработки оптимальных стратегий подавления РНК ВГС в Huh-7 клетках.

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