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3С-МЕТОДЫ В ИССЛЕДОВАНИЯХ ПРОСТРАНСТВЕННОЙ ОРГАНИЗАЦИИ ГЕНОМА
Аннотация
Пространственная трехмерная организация генома эукариот играет важную роль в функционировании ядерного материала. До недавнего времени единственной возможностью исследования пространственной организации генома в ядре клеток было использование методов световой и электронной микроскопии. Появление метода захвата конформации хромосом (chromosome conformation capture, 3С) позволило изучать хромосомные контакты, используя только молекулярно-биологические подходы. На сегодняшний день на основе 3С разработано целое семейство методов реконструкции пространственной организации генома.
Об авторах
Н. Р. БатуллинРоссия
В. С. Фишман
Россия
Ю. Л. Орлов
Россия
А. Г. Мензоров
Россия
Д. А. Афонников
Россия
О. Л. Серов
Россия
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