3С-МЕТОДЫ В ИССЛЕДОВАНИЯХ ПРОСТРАНСТВЕННОЙ ОРГАНИЗАЦИИ ГЕНОМА

Пространственная трехмерная организация генома эукариот играет важную роль в функционировании ядерного материала. До недавнего времени единственной возможностью исследования пространственной организации генома в ядре клеток было использование методов световой и электронной микроскопии. Появление метода захвата конформации хромосом (chromosome conformation capture, 3С) позволило изучать хромосомные контакты, используя только молекулярно-биологические подходы. На сегодняшний день на основе 3С разработано целое семейство методов реконструкции пространственной организации генома.

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