Polymorphism T3111C of the Clock gene in ethnic groups of women from Russia and Buryatia
https://doi.org/10.18699/VJ18.349
Abstract
Biological rhythms of organisms depend on both changing conditions of the external environment and internal “biological clock”. Circadian rhythms are the response of the organism to the change of day and night. They are some of the most important biological rhythms of organisms. Circadian rhythms are regulated by the group of circadian genes. It is known that women suffer from sleep disorders more often than men. Up to 50 % of menopausal women complain of problems associated with sleeping. The study involved 403 menopausal women aged from 45 to 60 years: 214 Russians (the average age is 52.74±6.28 years) and 189 Buryats (the average age is 51.95±5.13 years) living in Eastern Siberia (Irkutsk region, Irkutsk and Republic of Buryatia, Ulan-Ude). The prevalence of genotypes and alleles of the polymorphism T3111C of the circadian rhythm gene Clock (rs1801260) was studied in these groups. To this end, we conducted genotyping of DNA samples by polymerase chain reaction. It was shown that the compared groups have statistically significant differences in genotypes frequency (р = 0.001). It was found that in the group of Russian women the frequency of the TC genotype (p = 0.004) was significantly higher and the frequency of the TT genotype (p = 0.0001) was significantly lower than those in the sample of women of Buryatia. It was shown that in the group of Russian women allele 3111C is found in 30.4 % of cases, which is statistically significantly more often than in the group of Buryat women, where the frequency of allele 3111C was 19.3 % (p = 0.014).
About the Authors
O. V. Kaluzhnaya
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Irkutsk
Russian Federation
Irkutsk
N. V. Semenova
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Irkutsk
Russian Federation
Irkutsk
T. A. Bairova
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Irkutsk
Russian Federation
Irkutsk
I. M. Madaeva
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Irkutsk
Russian Federation
Irkutsk
E. V. Belyaeva
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Irkutsk
Russian Federation
Irkutsk
L. I. Kolesnikova
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Irkutsk
Russian Federation
Irkutsk
References
1. Bairova T.A., Dolgikh V.V., Kolesnikova L.I., Pervushina O.A. Nutriciogenetics and risk factors of cardiovascular disorders: an association study in Eastern Siberia populations. Acta Biomedica Scientifica. 2013;4(92):87-92. (in Russian)
2. Bairova T.A., Kolesnikov S.I., Kolesnikova L.I., Pervushina O.A., Darenskaya M.A., Grebenkina L.A. Lipid peroxidation and mitochondrial superoxide dismutase-2 gene in adolescents with essential hypertension. Byulleten eksperimentalnoy biologii i meditsiny = Bulletin of Experimental Biology and Medicine. 2014;8(158):141144. DOI 10.1007/s10517-014-2717-4. (in Russian)
3. Chernysheva M.P. Circadian oscillators and normones. Tsitologiya = Cytology. 2013;11(55):761-777. (in Russian)
4. Corella D., Asensio E.M., Coltell O., Sorli J.V., Estruch R., MartinezGonzalez M.A., Salas-Salvado J., Castaner O., Aros F., Lapetra J., Serra-Majem L., Gomes-Gracia E., Ortega-Azorin C., Fiol M., Espino J.D., Diaz-Lopez A., Fito M., Ros M., Ordavas J.M. CLOCK gene variation is associated with incidence of type-2 diabetes and cardiovascular diseases in type-2 diabetic subjects: dietary modulation in the PREDIMED randomized trial. Cardiovasc. Diabetol. 2016;15(4):1-12. DOI 10.1186/s12933-015-0327-8.
5. Dibner C., Schibler U. Circadian timing of metabolism in animal models and humans. J. Intern. Med. 2015;277(5):513-527. DOI 10.1111/ joim.12347.
6. Dunlap J.C. Molecular bases for circadian clocks. Cell. 1999;96(2): 271-290.
7. Fu L., Lee C.C. The circadian clock: pacemaker and tumor suppressor. Nat. Rev. Cancer. 2003;3:350-361. DOI 10.1038/nrc1072.
8. Kolesnikova L.I., Madaeva I.M., Semenova N.V., Suturina L.V., Berdina O.N., Sholohov L.F., Solodova E.I. Pathogenic role of melatonin in sleep disorders in menopausal women. Bull. Exp. Biol. Med. 2013;156(1):104-106.
9. Kolchanov N.A., Ignatieva E.V., Podkolodnaya O.A., Likhoshvai V.A., Matushkin Yu.G. Gene Networks. Vavilovskii Zhurnal Genetiki i Selektsii = Vavilov Journal of Genetics and Breeding. 2013;17(4/2):833-850. (in Russian)
10. Kolomeichuk S.N., Makeeva I.V., Topchieva L.V., Korneva V.A., Nemova N.N. Association of T3111C polymorphism in the 3ʹ-untranslated region of the Clock gene with the risk of essential arterial hypertension and coronary artery disease in the Russian population (residents of Karelia). Genetika = Genetics (Moscow). 2011;47(10):1411-1415. DOI 10.7868/S001667581604010X. (in Russian)
11. Kowalska E., Moriggi E., Bauer C., Dibner C., Brown S.A. The circadian clock starts ticking at a developmentally early stage. J. Biol. Rhythms. 2010;25:442-449. DOI 10.1177/0748730410385281.
12. Krystal A.D., Edinger J., Wohlgemuth W., Marsh G.R. Sleep in perimenopausal and post-menopausal women. Sleep Med. Rev. 1998; 4(2):243-253.
13. Loria-Kohen V., Espinosa-Salinas I., Marcos-Pasero H., LourençoNogueira T., Herranz J., Molina S., Reglero G., Ramirez de Molina A. Polymorphism in the CLOCK gene may influence the effect of fat intake reduction on weight loss. Nutrition. 2016;32(4):453460. DOI 10.1016/j.nut.2015.10.013.
14. Lowrey P.L., Shimomura K., Antoch M.P., Yamazaki S., Zemenides P.D., Ralph M.R., Menaker M., Takahashi J.S. Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau. Science. 2000;288(5465):483-492.
15. Madayeva I.M., Berdina O.N., Kolesnikova L.I., Bairova T.A., Ablamskaya O.N., Madaev V.V., Antonenko F.F. Ethnic features of sleep disorders in Eastern Siberia. Acta Biomedica Scientifica. 2013; 4(92):51-55. (in Russian)
16. Madayeva I.M., Semenova N.V., Danusevich I.N., Kolesnikova L.I. Climacteric syndrome, sleep disorders, and melatonin. Effektivnaya farmakoterapiya = Effective Pharmacotherapy. 2016;19:86-93. (in Russian)
17. Owens J.F., Matthews K.A. Sleep disturbance in healthy middle-aged women. Maturitas. 1998;30(1):41-50. Ozburn A.R., Purohit K., Parekh P.K., Kaplan G.N., Falcon E., Mukherjee S., Cates H.M., McClung C.A. Functional implications of the CLOCK 3111T/C single-nucleotide polymorphism. Front. Psychiatry. 2016;7(67):1-8. DOI 10.3389/fpsyt.2016.00067.
18. Pagani L., Semenova E.A., Moriggi E., Revell V.L., Hack L.M., Lockley S.W., Arendt J., Skene D.J., Meier F., Izakovic J., WirzJustice A., Cajochen C., Sergeeva O.J., Cheresiz S.V., Danilenko K.V., Eckert A., Brown S.A. The physiological period length of the human circadian clock in vivo is directly proportional to period in human fibroblasts. PLoS ONE. 2010; 5(10):1-17. DOI 10.1371/ journal.pone. 0013376.
19. Schmidt C., Peigneux P., Cajochen C. Age-related changes in sleep and circadian rhythms: impact on cognitive performance and underlying neuroanatomical networks. Front. Neurol. 2012;3(118):111. DOI 10.3389/fneur.2012.00118.
20. Solovyov I.A., Dobrovol’skaya E.V., Moskalev A.A. Genetic control of circadian rhythms and aging. Genetika = Genetics (Moscow). 2016; 52(4):393-413. DOI 10.7868/S001667581604010X. (in Russian)
21. Zhang B., Wing Y.K. Sex differences in insomnia: a meta-analysis. Sleep. 2006;29(1):85-93.
22. http://www.genecards.org
23. http://www.ensembl.org/Homo_sapiens/Variation/Population
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