Антоцианы как компоненты функционального питания

Среди встречающихся в природе пигментов антоцианы являются, пожалуй, одной из наиболее изученных групп. Начиная с первых исследований о физико-химических свойствах антоцианов, проведенных еще в XVII в. британским естествоиспытателем Р. Бойлем, наука об этих уникальных соединениях сделала огромный шаг вперед. На сегодняшний день достаточно хорошо исследованы структура и функции антоцианов в растительных клетках, а путь их биосинтеза – один из самых полно охарактеризованных путей биосинтеза вторичных метаболитов как на биохимическом, так и на генетическом уровне. Наряду с этими фундаментальными достижениями, мы начинаем осознавать потенциал антоцианов как соединений промышленного значения, как пигментов самих по себе, а также в качестве компонентов функционального питания, способствующих предупреждению и снижению риска развития хронических заболеваний. Долгое время биологическая активность антоцианов была недооценена, в частности, из-за данных об их низкой биодоступности. Однако в ходе исследований было показано, что в организме человека и животных эти соединения активно метаболизируются и биодоступность, оцененная с учетом их метаболитов, превышала 12 %. Экспериментально подтверждено, что антоцианы обладают антиоксидантными, противовоспалительными, гипогликемическими, антимутагенными, антидиабетическими, противораковыми, нейропротекторными свойствами, а также полезны для здоровья глаз. Однако проведенные исследования не всегда могут объяснить молекулярные механизмы действия антоцианов в организме человека. По некоторым данным, наблюдаемые эффекты объясняются действием не антоцианов, а их метаболитов, которые, благодаря своей повышенной биодоступности, могут быть более биологически активными, чем исходные соединения. Высказывается также предположение о положительном эффекте на здоровье человека всего комплекса полифенольных соединений, поступающего в организм в составе растительной пищи. В представленном обзоре суммированы результаты основных направлений исследований антоцианов в качестве компонентов функционального питания. Отдельное внимание уделено результатам генетических исследований синтеза пигментов, данные которых приобретают особую важность в связи с актуализацией селекционных программ, направленных на повышение содержания антоцианов у культурных растений.

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