ROLE OF HETEROZYGOUS TUMOR SUPPRESSORS IN THE LIFE LONGEVITY OF DROSOPHILA MELANOGASTER
Abstract
Role of tumor-suppressor genes in the life longevity has not been studied in detail. The purpose of the current work is to study the influence of heterozygous tumor suppressors on the life span of drosophila. We show that heterozygotes for l(3)hem, hyd, gd, ex or ft, both females and males, have a shorter life. The analysis of Gompertz curve parameters indicates that the l(3)hem, hyd or gd mutations increase age-related parameter (α) in males, while gd mutation increases the death background parameter (R) and the ex agerelated parameter in females. The effects of the mutations on the life span are probably associated with hedgehog (hyd), Notch (gd) и Hippo (ex и ft) signal transduction pathways.
About the Authors
S. A. Kopyl
Institute of Molecular and Cellular Biology SB RAS, Novosibirsk, Russia
Russian Federation
Russian Federation
L. V. Omelyanchuk
Institute of Molecular and Cellular Biology SB RAS, Novosibirsk, Russia
Russian Federation
Russian Federation
M. V. Shaposhnikov
Institute of Biоlogy, Komi Center of UB RAS, Syktivkar, Russia
Syktivkar State University, Russia
Russian Federation
Russian Federation
A. A. Moskalev
Institute of Biоlogy, Komi Center of UB RAS, Syktivkar, Russia
Syktivkar State University, Russia
Moscow Institute of Physics and Technology, Moscow, Russia
Russian Federation
Russian Federation
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